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Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties.
Ilyinsky NS, Shchyolkina AK, Borisova OF, Mamaeva OK, Zvereva MI, Azhibek DM, Livshits MA, Mitkevich VA, Balzarini J, Sinkevich YB, Luzikov YN, Dezhenkova LG, Kolotova ES, Shtil AA, Shchekotikhin AE, Kaluzhny DN. Ilyinsky NS, et al. Among authors: mitkevich va. Eur J Med Chem. 2014 Oct 6;85:605-14. doi: 10.1016/j.ejmech.2014.08.030. Epub 2014 Aug 8. Eur J Med Chem. 2014. PMID: 25127152
Hemoglobin is an oxygen-dependent glutathione buffer adapting the intracellular reduced glutathione levels to oxygen availability.
Fenk S, Melnikova EV, Anashkina AA, Poluektov YM, Zaripov PI, Mitkevich VA, Tkachev YV, Kaestner L, Minetti G, Mairbäurl H, Goede JS, Makarov AA, Petrushanko IY, Bogdanova A. Fenk S, et al. Among authors: mitkevich va. Redox Biol. 2022 Dec;58:102535. doi: 10.1016/j.redox.2022.102535. Epub 2022 Nov 16. Redox Biol. 2022. PMID: 36413919 Free PMC article.
Amyloid-β Increases Activity of Proteasomes Capped with 19S and 11S Regulators.
Morozov AV, Kulikova AA, Astakhova TM, Mitkevich VA, Burnysheva KM, Adzhubei AA, Erokhov PA, Evgen'ev MB, Sharova NP, Karpov VL, Makarov AA. Morozov AV, et al. Among authors: mitkevich va. J Alzheimers Dis. 2016 Sep 6;54(2):763-76. doi: 10.3233/JAD-160491. J Alzheimers Dis. 2016. PMID: 27567864
142 results