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Synthesis of atypical bile acids for use as investigative tools for the genetic defect of 3β-hydroxy-Δ(5)-C27-steroid oxidoreductase deficiency.
Gioiello A, Cerra B, Zhang W, Vallerini GP, Costantino G, De Franco F, Passeri D, Pellicciari R, Setchell KD. Gioiello A, et al. Among authors: costantino g. J Steroid Biochem Mol Biol. 2014 Oct;144 Pt B:348-60. doi: 10.1016/j.jsbmb.2014.06.008. Epub 2014 Jun 19. J Steroid Biochem Mol Biol. 2014. PMID: 24954360
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.
Pellicciari R, Costantino G, Camaioni E, Sadeghpour BM, Entrena A, Willson TM, Fiorucci S, Clerici C, Gioiello A. Pellicciari R, et al. Among authors: costantino g. J Med Chem. 2004 Aug 26;47(18):4559-69. doi: 10.1021/jm049904b. J Med Chem. 2004. PMID: 15317466
Pharmacophore model for bile acids recognition by the FPR receptor.
Ferrari C, Macchiarulo A, Costantino G, Pellicciari R. Ferrari C, et al. Among authors: costantino g. J Comput Aided Mol Des. 2006 May;20(5):295-303. doi: 10.1007/s10822-006-9055-1. Epub 2006 Sep 14. J Comput Aided Mol Des. 2006. PMID: 16972170
Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.
Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, Auwerx J. Pellicciari R, et al. Among authors: costantino g. J Med Chem. 2007 Sep 6;50(18):4265-8. doi: 10.1021/jm070633p. Epub 2007 Aug 9. J Med Chem. 2007. PMID: 17685603
552 results