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Validity of ligand efficiency metrics.
Murray CW, Erlanson DA, Hopkins AL, Keserü GM, Leeson PD, Rees DC, Reynolds CH, Richmond NJ. Murray CW, et al. Among authors: reynolds ch. ACS Med Chem Lett. 2014 May 9;5(6):616-8. doi: 10.1021/ml500146d. eCollection 2014 Jun 12. ACS Med Chem Lett. 2014. PMID: 24944729 Free PMC article.
The role of ligand efficiency metrics in drug discovery.
Hopkins AL, Keserü GM, Leeson PD, Rees DC, Reynolds CH. Hopkins AL, et al. Among authors: reynolds ch. Nat Rev Drug Discov. 2014 Feb;13(2):105-21. doi: 10.1038/nrd4163. Nat Rev Drug Discov. 2014. PMID: 24481311 Free article. Review.
Ligand efficiency metrics: why all the fuss?
Reynolds CH. Reynolds CH. Future Med Chem. 2015;7(11):1363-5. doi: 10.4155/fmc.15.70. Future Med Chem. 2015. PMID: 26230875 Free article. No abstract available.
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia.
Kelly MJ, Pietranico-Cole S, Larigan JD, Haynes NE, Reynolds CH, Scott N, Vermeulen J, Dvorozniak M, Conde-Knape K, Huang KS, So SS, Thakkar K, Qian Y, Banner B, Mennona F, Danzi S, Klein I, Taub R, Tilley J. Kelly MJ, et al. Among authors: reynolds ch. J Med Chem. 2014 May 22;57(10):3912-23. doi: 10.1021/jm4019299. Epub 2014 Apr 8. J Med Chem. 2014. PMID: 24712661
The role of molecular size in ligand efficiency.
Reynolds CH, Bembenek SD, Tounge BA. Reynolds CH, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4258-61. doi: 10.1016/j.bmcl.2007.05.038. Epub 2007 May 17. Bioorg Med Chem Lett. 2007. PMID: 17532632
Ligand efficiency and fragment-based drug discovery.
Bembenek SD, Tounge BA, Reynolds CH. Bembenek SD, et al. Among authors: reynolds ch. Drug Discov Today. 2009 Mar;14(5-6):278-83. doi: 10.1016/j.drudis.2008.11.007. Epub 2008 Dec 30. Drug Discov Today. 2009. PMID: 19073276 Review.
110 results