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Validity of ligand efficiency metrics.
Murray CW, Erlanson DA, Hopkins AL, Keserü GM, Leeson PD, Rees DC, Reynolds CH, Richmond NJ. Murray CW, et al. Among authors: leeson pd. ACS Med Chem Lett. 2014 May 9;5(6):616-8. doi: 10.1021/ml500146d. eCollection 2014 Jun 12. ACS Med Chem Lett. 2014. PMID: 24944729 Free PMC article.
The role of ligand efficiency metrics in drug discovery.
Hopkins AL, Keserü GM, Leeson PD, Rees DC, Reynolds CH. Hopkins AL, et al. Among authors: leeson pd. Nat Rev Drug Discov. 2014 Feb;13(2):105-21. doi: 10.1038/nrd4163. Nat Rev Drug Discov. 2014. PMID: 24481311 Free article. Review.
Next generation therapeutics.
Leeson PD, Rees DC. Leeson PD, et al. Curr Opin Chem Biol. 1999 Aug;3(4):369-72. doi: 10.1016/s1367-5931(99)80055-6. Curr Opin Chem Biol. 1999. PMID: 10419859 No abstract available.
Molecular Property Design: Does Everyone Get It?
Leeson PD, Young RJ. Leeson PD, et al. ACS Med Chem Lett. 2015 May 27;6(7):722-5. doi: 10.1021/acsmedchemlett.5b00157. eCollection 2015 Jul 9. ACS Med Chem Lett. 2015. PMID: 26191353 Free PMC article.
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
Cheshire DR, Åberg A, Andersson GM, Andrews G, Beaton HG, Birkinshaw TN, Boughton-Smith N, Connolly S, Cook TR, Cooper A, Cooper SL, Cox D, Dixon J, Gensmantel N, Hamley PJ, Harrison R, Hartopp P, Käck H, Leeson PD, Luker T, Mete A, Millichip I, Nicholls DJ, Pimm AD, St-Gallay SA, Wallace AV. Cheshire DR, et al. Among authors: leeson pd. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2468-71. doi: 10.1016/j.bmcl.2011.02.061. Epub 2011 Feb 18. Bioorg Med Chem Lett. 2011. PMID: 21398123
67 results