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Validity of ligand efficiency metrics.
Murray CW, Erlanson DA, Hopkins AL, Keserü GM, Leeson PD, Rees DC, Reynolds CH, Richmond NJ. Murray CW, et al. Among authors: hopkins al. ACS Med Chem Lett. 2014 May 9;5(6):616-8. doi: 10.1021/ml500146d. eCollection 2014 Jun 12. ACS Med Chem Lett. 2014. PMID: 24944729 Free PMC article.
The role of ligand efficiency metrics in drug discovery.
Hopkins AL, Keserü GM, Leeson PD, Rees DC, Reynolds CH. Hopkins AL, et al. Nat Rev Drug Discov. 2014 Feb;13(2):105-21. doi: 10.1038/nrd4163. Nat Rev Drug Discov. 2014. PMID: 24481311 Free article. Review.
Fragment screening by surface plasmon resonance.
Navratilova I, Hopkins AL. Navratilova I, et al. Among authors: hopkins al. ACS Med Chem Lett. 2010 Feb 4;1(1):44-8. doi: 10.1021/ml900002k. eCollection 2010 Apr 8. ACS Med Chem Lett. 2010. PMID: 24900174 Free PMC article.
Screening for GPCR Ligands Using Surface Plasmon Resonance.
Navratilova I, Besnard J, Hopkins AL. Navratilova I, et al. Among authors: hopkins al. ACS Med Chem Lett. 2011 Jul 14;2(7):549-554. doi: 10.1021/ml2000017. Epub 2011 May 16. ACS Med Chem Lett. 2011. PMID: 21765967 Free PMC article.
Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.
Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, Hopkins AL, Lefkowitz RJ, Navratilova I. Aristotelous T, et al. Among authors: hopkins al. ACS Med Chem Lett. 2013 Oct 10;4(10):1005-1010. doi: 10.1021/ml400312j. Epub 2013 Sep 3. ACS Med Chem Lett. 2013. PMID: 24454993 Free PMC article.
Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.
Navratilova I, Aristotelous T, Picaud S, Chaikuad A, Knapp S, Filappakopoulos P, Hopkins AL. Navratilova I, et al. Among authors: hopkins al. ACS Med Chem Lett. 2016 Sep 20;7(12):1213-1218. doi: 10.1021/acsmedchemlett.6b00154. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994766 Free PMC article.
Rapid analysis of pharmacology for infectious diseases.
Hopkins AL, Bickerton GR, Carruthers IM, Boyer SK, Rubin H, Overington JP. Hopkins AL, et al. Curr Top Med Chem. 2011;11(10):1292-300. doi: 10.2174/156802611795429130. Curr Top Med Chem. 2011. PMID: 21401504 Free PMC article. Review.
Quantifying the chemical beauty of drugs.
Bickerton GR, Paolini GV, Besnard J, Muresan S, Hopkins AL. Bickerton GR, et al. Among authors: hopkins al. Nat Chem. 2012 Jan 24;4(2):90-8. doi: 10.1038/nchem.1243. Nat Chem. 2012. PMID: 22270643 Free PMC article.
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH. Freeman GA, et al. Among authors: hopkins al. J Med Chem. 2004 Nov 18;47(24):5923-36. doi: 10.1021/jm040072r. J Med Chem. 2004. PMID: 15537347
100 results