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GPR103 antagonists demonstrating anorexigenic activity in vivo: design and development of pyrrolo[2,3-c]pyridines that mimic the C-terminal Arg-Phe motif of QRFP26.
Georgsson J, Bergström F, Nordqvist A, Watson MJ, Blundell CD, Johansson MJ, Petersson AU, Yuan ZQ, Zhou Y, Kristensson L, Kakol-Palm D, Tyrchan C, Wellner E, Bauer U, Brodin P, Svensson Henriksson A. Georgsson J, et al. Among authors: yuan zq. J Med Chem. 2014 Jul 24;57(14):5935-48. doi: 10.1021/jm401951t. Epub 2014 Jul 2. J Med Chem. 2014. PMID: 24937104
Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26.
Georgsson J, Bergström F, Nordqvist A, Watson MJ, Blundell CD, Johansson MJ, Petersson AU, Yuan ZQ, Zhou Y, Kristensson L, Kakol-Palm D, Tyrchan C, Wellner E, Bauer U, Brodin P, Svensson Henriksson A. Georgsson J, et al. Among authors: yuan zq. J Med Chem. 2015 May 14;58(9):4086. doi: 10.1021/acs.jmedchem.5b00479. Epub 2015 Apr 15. J Med Chem. 2015. PMID: 25875054 No abstract available.
Identification and design of a novel series of MGAT2 inhibitors.
Barlind JG, Buckett LK, Crosby SG, Davidsson Ö, Emtenäs H, Ertan A, Jurva U, Lemurell M, Gutierrez PM, Nilsson K, O'Mahony G, Petersson AU, Redzic A, Wågberg F, Yuan ZQ. Barlind JG, et al. Among authors: yuan zq. Bioorg Med Chem Lett. 2013 May 1;23(9):2721-6. doi: 10.1016/j.bmcl.2013.02.084. Epub 2013 Feb 27. Bioorg Med Chem Lett. 2013. PMID: 23541669
Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
Granberg KL, Yuan ZQ, Lindmark B, Edman K, Kajanus J, Hogner A, Malmgren M, O'Mahony G, Nordqvist A, Lindberg J, Tångefjord S, Kossenjans M, Löfberg C, Brånalt J, Liu D, Selmi N, Nikitidis G, Nordberg P, Hayen A, Aagaard A, Hansson E, Hermansson M, Ivarsson I, Jansson-Löfmark R, Karlsson U, Johansson U, William-Olsson L, Hartleib-Geschwindner J, Bamberg K. Granberg KL, et al. Among authors: yuan zq. J Med Chem. 2019 Feb 14;62(3):1385-1406. doi: 10.1021/acs.jmedchem.8b01523. Epub 2019 Jan 30. J Med Chem. 2019. PMID: 30596500
Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach.
Kajanus J, Jacobson I, Åstrand A, Olsson RI, Gran U, Björe A, Fjellström O, Davidsson Ö, Emtenäs H, Dahlén A, Löfberg B, Yuan ZQ, Sundell J, Cassel J, Gyll J, Iliefski T, Högberg Å, Lindhardt E, Malmberg J. Kajanus J, et al. Among authors: yuan zq. Bioorg Med Chem Lett. 2016 Apr 15;26(8):2023-9. doi: 10.1016/j.bmcl.2016.02.081. Epub 2016 Mar 2. Bioorg Med Chem Lett. 2016. PMID: 26965854
Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance.
Giordanetto F, Wållberg A, Ghosal S, Iliefski T, Cassel J, Yuan ZQ, von Wachenfeldt H, Andersen SM, Inghardt T, Tunek A, Nylander S. Giordanetto F, et al. Among authors: yuan zq. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6671-6. doi: 10.1016/j.bmcl.2012.08.102. Epub 2012 Sep 6. Bioorg Med Chem Lett. 2012. PMID: 23010262
Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation.
Giordanetto F, Wållberg A, Cassel J, Ghosal S, Kossenjans M, Yuan ZQ, Wang X, Liang L. Giordanetto F, et al. Among authors: yuan zq. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6665-70. doi: 10.1016/j.bmcl.2012.08.101. Epub 2012 Sep 7. Bioorg Med Chem Lett. 2012. PMID: 23010274
Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel.
Olsson RI, Jacobson I, Iliefski T, Boström J, Davidsson Ö, Fjellström O, Björe A, Olsson C, Sundell J, Gran U, Gyll J, Malmberg J, Hidestål O, Emtenäs H, Svensson T, Yuan ZQ, Strandlund G, Åstrand A, Lindhardt E, Linhardt G, Forsström E, Högberg Å, Persson F, Andersson B, Rönnborg A, Löfberg B. Olsson RI, et al. Among authors: yuan zq. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1269-73. doi: 10.1016/j.bmcl.2014.01.067. Epub 2014 Jan 30. Bioorg Med Chem Lett. 2014. PMID: 24513046
177 results