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GPR103 antagonists demonstrating anorexigenic activity in vivo: design and development of pyrrolo[2,3-c]pyridines that mimic the C-terminal Arg-Phe motif of QRFP26.
Georgsson J, Bergström F, Nordqvist A, Watson MJ, Blundell CD, Johansson MJ, Petersson AU, Yuan ZQ, Zhou Y, Kristensson L, Kakol-Palm D, Tyrchan C, Wellner E, Bauer U, Brodin P, Svensson Henriksson A. Georgsson J, et al. Among authors: brodin p. J Med Chem. 2014 Jul 24;57(14):5935-48. doi: 10.1021/jm401951t. Epub 2014 Jul 2. J Med Chem. 2014. PMID: 24937104
A modeling approach for compounds affecting body composition.
Gennemark P, Jansson-Löfmark R, Hyberg G, Wigstrand M, Kakol-Palm D, Håkansson P, Hovdal D, Brodin P, Fritsch-Fredin M, Antonsson M, Ploj K, Gabrielsson J. Gennemark P, et al. Among authors: brodin p. J Pharmacokinet Pharmacodyn. 2013 Dec;40(6):651-67. doi: 10.1007/s10928-013-9337-x. Epub 2013 Oct 25. J Pharmacokinet Pharmacodyn. 2013. PMID: 24158456
Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26.
Georgsson J, Bergström F, Nordqvist A, Watson MJ, Blundell CD, Johansson MJ, Petersson AU, Yuan ZQ, Zhou Y, Kristensson L, Kakol-Palm D, Tyrchan C, Wellner E, Bauer U, Brodin P, Svensson Henriksson A. Georgsson J, et al. Among authors: brodin p. J Med Chem. 2015 May 14;58(9):4086. doi: 10.1021/acs.jmedchem.5b00479. Epub 2015 Apr 15. J Med Chem. 2015. PMID: 25875054 No abstract available.
Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties.
Johansson A, Löfberg C, Antonsson M, von Unge S, Hayes MA, Judkins R, Ploj K, Benthem L, Lindén D, Brodin P, Wennerberg M, Fredenwall M, Li L, Persson J, Bergman R, Pettersen A, Gennemark P, Hogner A. Johansson A, et al. Among authors: brodin p. J Med Chem. 2016 Mar 24;59(6):2497-511. doi: 10.1021/acs.jmedchem.5b01654. Epub 2016 Feb 5. J Med Chem. 2016. PMID: 26741166
Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.
Bohlooly-Y M, Olsson B, Bruder CE, Lindén D, Sjögren K, Bjursell M, Egecioglu E, Svensson L, Brodin P, Waterton JC, Isaksson OG, Sundler F, Ahrén B, Ohlsson C, Oscarsson J, Törnell J. Bohlooly-Y M, et al. Among authors: brodin p. Diabetes. 2005 Jan;54(1):51-62. doi: 10.2337/diabetes.54.1.51. Diabetes. 2005. PMID: 15616010
Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican.
Jönsson-Rylander AC, Nilsson T, Fritsche-Danielson R, Hammarström A, Behrendt M, Andersson JO, Lindgren K, Andersson AK, Wallbrandt P, Rosengren B, Brodin P, Thelin A, Westin A, Hurt-Camejo E, Lee-Søgaard CH. Jönsson-Rylander AC, et al. Among authors: brodin p. Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):180-5. doi: 10.1161/01.ATV.0000150045.27127.37. Epub 2004 Nov 11. Arterioscler Thromb Vasc Biol. 2005. PMID: 15539621
Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.
Agudelo LZ, Ferreira DMS, Cervenka I, Bryzgalova G, Dadvar S, Jannig PR, Pettersson-Klein AT, Lakshmikanth T, Sustarsic EG, Porsmyr-Palmertz M, Correia JC, Izadi M, Martínez-Redondo V, Ueland PM, Midttun Ø, Gerhart-Hines Z, Brodin P, Pereira T, Berggren PO, Ruas JL. Agudelo LZ, et al. Among authors: brodin p. Cell Metab. 2018 Feb 6;27(2):378-392.e5. doi: 10.1016/j.cmet.2018.01.004. Cell Metab. 2018. PMID: 29414686 Free article.
A novel role of the checkpoint kinase ATR in leptin signaling.
Ericson E, Wennberg Huldt C, Strömstedt M, Brodin P. Ericson E, et al. Among authors: brodin p. Mol Cell Endocrinol. 2015 Sep 5;412:257-64. doi: 10.1016/j.mce.2015.04.034. Epub 2015 May 14. Mol Cell Endocrinol. 2015. PMID: 25980679 Free article.
355 results