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Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.
Boeckler FM, Joerger AC, Jaggi G, Rutherford TJ, Veprintsev DB, Fersht AR. Boeckler FM, et al. Among authors: joerger ac. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. doi: 10.1073/pnas.0805326105. Epub 2008 Jul 23. Proc Natl Acad Sci U S A. 2008. PMID: 18650397 Free PMC article.
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53.
Wilcken R, Liu X, Zimmermann MO, Rutherford TJ, Fersht AR, Joerger AC, Boeckler FM. Wilcken R, et al. Among authors: joerger ac. J Am Chem Soc. 2012 Apr 18;134(15):6810-8. doi: 10.1021/ja301056a. Epub 2012 Apr 5. J Am Chem Soc. 2012. PMID: 22439615 Free PMC article.
Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.
Vogel SM, Bauer MR, Joerger AC, Wilcken R, Brandt T, Veprintsev DB, Rutherford TJ, Fersht AR, Boeckler FM. Vogel SM, et al. Among authors: joerger ac. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16906-10. doi: 10.1073/pnas.1215060109. Epub 2012 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 23035244 Free PMC article.
Small molecule induced reactivation of mutant p53 in cancer cells.
Liu X, Wilcken R, Joerger AC, Chuckowree IS, Amin J, Spencer J, Fersht AR. Liu X, et al. Among authors: joerger ac. Nucleic Acids Res. 2013 Jul;41(12):6034-44. doi: 10.1093/nar/gkt305. Epub 2013 Apr 29. Nucleic Acids Res. 2013. PMID: 23630318 Free PMC article.
65 results