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Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.
Sajan MP, Jurzak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV. Sajan MP, et al. Among authors: leitges m. Adipocyte. 2014 Jan 1;3(1):19-29. doi: 10.4161/adip.26305. Epub 2013 Sep 10. Adipocyte. 2014. PMID: 24575365 Free PMC article.
Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.
Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP. Dorfman MD, et al. Among authors: leitges m. Diabetes. 2017 Apr;66(4):920-934. doi: 10.2337/db16-0482. Epub 2017 Jan 10. Diabetes. 2017. PMID: 28073831 Free PMC article.
Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.
Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM, Farese RV. Sajan MP, et al. Among authors: leitges m. Neurobiol Aging. 2018 Jan;61:225-237. doi: 10.1016/j.neurobiolaging.2017.09.001. Epub 2017 Sep 15. Neurobiol Aging. 2018. PMID: 29032894 Free PMC article.
234 results