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Basal gene expression by lung CD4+ T cells in chronic obstructive pulmonary disease identifies independent molecular correlates of airflow obstruction and emphysema extent.
Freeman CM, McCubbrey AL, Crudgington S, Nelson J, Martinez FJ, Han MK, Washko GR Jr, Chensue SW, Arenberg DA, Meldrum CA, McCloskey L, Curtis JL. Freeman CM, et al. Among authors: mccloskey l. PLoS One. 2014 May 7;9(5):e96421. doi: 10.1371/journal.pone.0096421. eCollection 2014. PLoS One. 2014. PMID: 24805101 Free PMC article.
Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease.
Freeman CM, Martinez FJ, Han MK, Ames TM, Chensue SW, Todt JC, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL. Freeman CM, et al. Among authors: mccloskey l. Am J Respir Crit Care Med. 2009 Dec 15;180(12):1179-88. doi: 10.1164/rccm.200904-0552OC. Epub 2009 Sep 3. Am J Respir Crit Care Med. 2009. PMID: 19729666 Free PMC article.
Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15.
Freeman CM, Han MK, Martinez FJ, Murray S, Liu LX, Chensue SW, Polak TJ, Sonstein J, Todt JC, Ames TM, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL. Freeman CM, et al. Among authors: mccloskey l. J Immunol. 2010 Jun 1;184(11):6504-13. doi: 10.4049/jimmunol.1000006. Epub 2010 Apr 28. J Immunol. 2010. PMID: 20427767 Free PMC article.
Analysis of the lung microbiome in the "healthy" smoker and in COPD.
Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Schmidt LA, Young VB, Toews GB, Curtis JL, Sundaram B, Martinez FJ, Huffnagle GB. Erb-Downward JR, et al. Among authors: mccloskey l. PLoS One. 2011 Feb 22;6(2):e16384. doi: 10.1371/journal.pone.0016384. PLoS One. 2011. PMID: 21364979 Free PMC article. Clinical Trial.
Lung CD8+ T cells in COPD have increased expression of bacterial TLRs.
Freeman CM, Martinez FJ, Han MK, Washko GR Jr, McCubbrey AL, Chensue SW, Arenberg DA, Meldrum CA, McCloskey L, Curtis JL. Freeman CM, et al. Among authors: mccloskey l. Respir Res. 2013 Feb 1;14(1):13. doi: 10.1186/1465-9921-14-13. Respir Res. 2013. PMID: 23374856 Free PMC article. Clinical Trial.
Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood.
Freeman CM, Martinez CH, Todt JC, Martinez FJ, Han MK, Thompson DL, McCloskey L, Curtis JL. Freeman CM, et al. Among authors: mccloskey l. Respir Res. 2015 Aug 5;16(1):94. doi: 10.1186/s12931-015-0251-1. Respir Res. 2015. PMID: 26243260 Free PMC article. Clinical Trial.
Human lung cDC1 drive increased perforin-mediated NK cytotoxicity in chronic obstructive pulmonary disease.
Pallazola AM, Rao JX, Mengistu DT, Morcos MS, Toma MS, Stolberg VR, Tretyakova A, McCloskey L, Curtis JL, Freeman CM. Pallazola AM, et al. Among authors: mccloskey l. Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1;321(6):L1183-L1193. doi: 10.1152/ajplung.00322.2020. Epub 2021 Oct 27. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 34704847 Free PMC article.
151 results