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A highly efficient asymmetric synthesis of vernakalant.
Limanto J, Ashley ER, Yin J, Beutner GL, Grau BT, Kassim AM, Kim MM, Klapars A, Liu Z, Strotman HR, Truppo MD. Limanto J, et al. Org Lett. 2014 May 16;16(10):2716-9. doi: 10.1021/ol501002a. Epub 2014 May 1. Org Lett. 2014. PMID: 24786635
Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor.
Zhong YL, Cleator E, Liu Z, Yin J, Morris WJ, Alam M, Bishop B, Dumas AM, Edwards J, Goodyear A, Mullens P, Song ZJ, Shevlin M, Thaisrivongs DA, Li H, Sherer EC, Cohen RD, Yin J, Tan L, Yasuda N, Limanto J, Davies A, Campos KR. Zhong YL, et al. Among authors: limanto j. J Org Chem. 2019 Apr 19;84(8):4780-4795. doi: 10.1021/acs.joc.8b02500. Epub 2018 Dec 10. J Org Chem. 2019. PMID: 30475616
Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods.
Klapars A, Chung JYL, Limanto J, Calabria R, Campeau LC, Campos KR, Chen W, Dalby SM, Davis TA, DiRocco DA, Hyde AM, Kassim AM, Larsen MU, Liu G, Maligres PE, Moment A, Peng F, Ruck RT, Shevlin M, Simmons BL, Song ZJ, Tan L, Wright TJ, Zultanski SL. Klapars A, et al. Among authors: limanto j. Chem Sci. 2021 May 19;12(26):9031-9036. doi: 10.1039/d1sc01978c. eCollection 2021 Jul 7. Chem Sci. 2021. PMID: 34276931 Free PMC article.
A multifunctional catalyst that stereoselectively assembles prodrugs.
DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW. DiRocco DA, et al. Among authors: limanto j. Science. 2017 Apr 28;356(6336):426-430. doi: 10.1126/science.aam7936. Science. 2017. PMID: 28450641
Supercritical fluid chromatography-photodiode array detection-electrospray ionization mass spectrometry as a framework for impurity fate mapping in the development and manufacture of drug substances.
Pirrone GF, Mathew RM, Makarov AA, Bernardoni F, Klapars A, Hartman R, Limanto J, Regalado EL. Pirrone GF, et al. Among authors: limanto j. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 30;1080:42-49. doi: 10.1016/j.jchromb.2018.02.006. Epub 2018 Feb 8. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 29477066
17 results