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An N-terminal threonine mutation produces an efflux-favorable, sodium-primed conformation of the human dopamine transporter.
Mol Pharmacol. 2014 Jul;86(1):76-85. doi: 10.1124/mol.114.091926. Epub 2014 Apr 21.
Mol Pharmacol. 2014.
PMID: 24753048
Free PMC article.
Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats.
Perry ML, Leinninger GM, Chen R, Luderman KD, Yang H, Gnegy ME, Myers MG Jr, Kennedy RT.
Perry ML, et al. Among authors: luderman kd.
J Neurochem. 2010 Aug;114(3):666-74. doi: 10.1111/j.1471-4159.2010.06757.x. Epub 2010 Apr 20.
J Neurochem. 2010.
PMID: 20412389
Free PMC article.
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Protein kinase C beta regulates the D₂-like dopamine autoreceptor.
Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME.
Luderman KD, et al.
Neuropharmacology. 2015 Feb;89:335-41. doi: 10.1016/j.neuropharm.2014.10.012.
Neuropharmacology. 2015.
PMID: 25446677
Free PMC article.
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Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites.
Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aubé J, Lane JR, Frankowski KJ, Sibley DR.
Luderman KD, et al.
Mol Pharmacol. 2018 Oct;94(4):1197-1209. doi: 10.1124/mol.118.113175. Epub 2018 Aug 1.
Mol Pharmacol. 2018.
PMID: 30068735
Free PMC article.
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Development of pyrimidone D1 dopamine receptor positive allosteric modulators.
Luderman KD, Jain P, Benjamin Free R, Conroy JL, Aubé J, Sibley DR, Frankowski KJ.
Luderman KD, et al.
Bioorg Med Chem Lett. 2021 Jan 1;31:127696. doi: 10.1016/j.bmcl.2020.127696. Epub 2020 Nov 19.
Bioorg Med Chem Lett. 2021.
PMID: 33221389
Free PMC article.
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Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential.
Sibley DR, Luderman KD, Free RB, Shi L.
Sibley DR, et al. Among authors: luderman kd.
Signal Transduct Target Ther. 2021 May 22;6(1):205. doi: 10.1038/s41392-021-00630-3.
Signal Transduct Target Ther. 2021.
PMID: 34023856
Free PMC article.
No abstract available.
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A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors.
Bocarsly ME, da Silva E Silva D, Kolb V, Luderman KD, Shashikiran S, Rubinstein M, Sibley DR, Dobbs LK, Alvarez VA.
Bocarsly ME, et al. Among authors: luderman kd.
Cell Rep. 2019 Oct 29;29(5):1147-1163.e5. doi: 10.1016/j.celrep.2019.09.059.
Cell Rep. 2019.
PMID: 31665630
Free PMC article.
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