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Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.
D'Ascenzio M, Carradori S, Secci D, Mannina L, Sobolev AP, De Monte C, Cirilli R, Yáñez M, Alcaro S, Ortuso F. D'Ascenzio M, et al. Among authors: cirilli r. Bioorg Med Chem. 2014 May 15;22(10):2887-95. doi: 10.1016/j.bmc.2014.03.042. Epub 2014 Apr 5. Bioorg Med Chem. 2014. PMID: 24746464
Enantiomers of C(5)-chiral 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives: Analytical and semipreparative HPLC separation, chiroptical properties, absolute configuration, and inhibitory activity against monoamine oxidase.
Cirilli R, Ferretti R, Gallinella B, Turchetto L, Bolasco A, Secci D, Chimenti P, Pierini M, Fares V, Befani O, La Torre F. Cirilli R, et al. Chirality. 2004 Nov;16(9):625-36. doi: 10.1002/chir.20085. Chirality. 2004. PMID: 15382204
Analytical and semipreparative high performance liquid chromatography enantioseparation of new substituted 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazoles on polysaccharide-based chiral stationary phases in normal-phase, polar organic and reversed-phase conditions.
Cirilli R, Simonelli A, Ferretti R, Bolasco A, Chimenti P, Secci D, Maccioni E, La Torre F. Cirilli R, et al. J Chromatogr A. 2006 Jan 6;1101(1-2):198-203. doi: 10.1016/j.chroma.2005.10.003. Epub 2005 Oct 24. J Chromatogr A. 2006. PMID: 16246349
Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives.
Chimenti F, Maccioni E, Secci D, Bolasco A, Chimenti P, Granese A, Befani O, Turini P, Alcaro S, Ortuso F, Cirilli R, La Torre F, Cardia MC, Distinto S. Chimenti F, et al. Among authors: cirilli r. J Med Chem. 2005 Nov 17;48(23):7113-22. doi: 10.1021/jm040903t. J Med Chem. 2005. PMID: 16279769
Synthesis, biological evaluation and 3D-QSAR of 1,3,5-trisubstituted-4,5-dihydro-(1H)-pyrazole derivatives as potent and highly selective monoamine oxidase A inhibitors.
Chimenti F, Bolasco A, Manna F, Secci D, Chimenti P, Granese A, Befani O, Turini P, Cirilli R, La Torre F, Alcaro S, Ortuso F, Langer T. Chimenti F, et al. Among authors: cirilli r. Curr Med Chem. 2006;13(12):1411-28. doi: 10.2174/092986706776872907. Curr Med Chem. 2006. PMID: 16719786 Review.
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant.
Silvestri R, Marfè G, Artico M, La Regina G, Lavecchia A, Novellino E, Morgante E, Di Stefano C, Catalano G, Filomeni G, Abruzzese E, Ciriolo MR, Russo MA, Amadori S, Cirilli R, La Torre F, Sinibaldi Salimei P. Silvestri R, et al. Among authors: cirilli r. J Med Chem. 2006 Sep 21;49(19):5840-4. doi: 10.1021/jm0602716. J Med Chem. 2006. PMID: 16970408 Free article.
1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies.
La Regina G, D'Auria FD, Tafi A, Piscitelli F, Olla S, Caporuscio F, Nencioni L, Cirilli R, La Torre F, De Melo NR, Kelly SL, Lamb DC, Artico M, Botta M, Palamara AT, Silvestri R. La Regina G, et al. Among authors: cirilli r. J Med Chem. 2008 Jul 10;51(13):3841-55. doi: 10.1021/jm800009r. Epub 2008 Jun 5. J Med Chem. 2008. PMID: 18529046
151 results