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Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.
Trenholme K, Marek L, Duffy S, Pradel G, Fisher G, Hansen FK, Skinner-Adams TS, Butterworth A, Ngwa CJ, Moecking J, Goodman CD, McFadden GI, Sumanadasa SD, Fairlie DP, Avery VM, Kurz T, Andrews KT. Trenholme K, et al. Among authors: fairlie dp. Antimicrob Agents Chemother. 2014 Jul;58(7):3666-78. doi: 10.1128/AAC.02721-13. Epub 2014 Apr 14. Antimicrob Agents Chemother. 2014. PMID: 24733477 Free PMC article.
Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria.
Andrews KT, Fairlie DP, Madala PK, Ray J, Wyatt DM, Hilton PM, Melville LA, Beattie L, Gardiner DL, Reid RC, Stoermer MJ, Skinner-Adams T, Berry C, McCarthy JS. Andrews KT, et al. Among authors: fairlie dp. Antimicrob Agents Chemother. 2006 Feb;50(2):639-48. doi: 10.1128/AAC.50.2.639-648.2006. Antimicrob Agents Chemother. 2006. PMID: 16436721 Free PMC article.
Potent antimalarial activity of histone deacetylase inhibitor analogues.
Andrews KT, Tran TN, Lucke AJ, Kahnberg P, Le GT, Boyle GM, Gardiner DL, Skinner-Adams TS, Fairlie DP. Andrews KT, et al. Among authors: fairlie dp. Antimicrob Agents Chemother. 2008 Apr;52(4):1454-61. doi: 10.1128/AAC.00757-07. Epub 2008 Jan 22. Antimicrob Agents Chemother. 2008. PMID: 18212103 Free PMC article.
Inhibitors selective for HDAC6 in enzymes and cells.
Gupta PK, Reid RC, Liu L, Lucke AJ, Broomfield SA, Andrews MR, Sweet MJ, Fairlie DP. Gupta PK, et al. Among authors: fairlie dp. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7067-70. doi: 10.1016/j.bmcl.2010.09.100. Epub 2010 Oct 12. Bioorg Med Chem Lett. 2010. PMID: 20947351
Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax.
Marfurt J, Chalfein F, Prayoga P, Wabiser F, Kenangalem E, Piera KA, Fairlie DP, Tjitra E, Anstey NM, Andrews KT, Price RN. Marfurt J, et al. Among authors: fairlie dp. Antimicrob Agents Chemother. 2011 Mar;55(3):961-6. doi: 10.1128/AAC.01220-10. Epub 2010 Dec 6. Antimicrob Agents Chemother. 2011. PMID: 21135175 Free PMC article.
394 results