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The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.
Genes Dev. 2014 Apr 1;28(7):749-64. doi: 10.1101/gad.236513.113.
Genes Dev. 2014.
PMID: 24696456
Free PMC article.
The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation.
Loedige I, Jakob L, Treiber T, Ray D, Stotz M, Treiber N, Hennig J, Cook KB, Morris Q, Hughes TR, Engelmann JC, Krahn MP, Meister G.
Loedige I, et al.
Cell Rep. 2015 Nov 10;13(6):1206-1220. doi: 10.1016/j.celrep.2015.09.068. Epub 2015 Oct 29.
Cell Rep. 2015.
PMID: 26527002
Free article.
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The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.
Loedige I, Gaidatzis D, Sack R, Meister G, Filipowicz W.
Loedige I, et al.
Nucleic Acids Res. 2013 Jan 7;41(1):518-32. doi: 10.1093/nar/gks1032. Epub 2012 Nov 3.
Nucleic Acids Res. 2013.
PMID: 23125361
Free PMC article.
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The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda.
Reichardt I, Bonnay F, Steinmann V, Loedige I, Burkard TR, Meister G, Knoblich JA.
Reichardt I, et al. Among authors: loedige i.
EMBO Rep. 2018 Jan;19(1):102-117. doi: 10.15252/embr.201744188. Epub 2017 Nov 30.
EMBO Rep. 2018.
PMID: 29191977
Free PMC article.
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Structure and dynamics of the quaternary hunchback mRNA translation repression complex.
Macošek J, Simon B, Linse JB, Jagtap PKA, Winter SL, Foot J, Lapouge K, Perez K, Rettel M, Ivanović MT, Masiewicz P, Murciano B, Savitski MM, Loedige I, Hub JS, Gabel F, Hennig J.
Macošek J, et al. Among authors: loedige i.
Nucleic Acids Res. 2021 Sep 7;49(15):8866-8885. doi: 10.1093/nar/gkab635.
Nucleic Acids Res. 2021.
PMID: 34329466
Free PMC article.
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TRIM-NHL proteins take on miRNA regulation.
Loedige I, Filipowicz W.
Loedige I, et al.
Cell. 2009 Mar 6;136(5):818-20. doi: 10.1016/j.cell.2009.02.030.
Cell. 2009.
PMID: 19269362
Free article.
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The widespread regulation of microRNA biogenesis, function and decay.
Krol J, Loedige I, Filipowicz W.
Krol J, et al. Among authors: loedige i.
Nat Rev Genet. 2010 Sep;11(9):597-610. doi: 10.1038/nrg2843. Epub 2010 Jul 27.
Nat Rev Genet. 2010.
PMID: 20661255
Review.
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mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons.
Loedige I, Baranovskii A, Mendonsa S, Dantsuji S, Popitsch N, Breimann L, Zerna N, Cherepanov V, Milek M, Ameres S, Chekulaeva M.
Loedige I, et al.
Mol Cell. 2023 Aug 3;83(15):2709-2725.e10. doi: 10.1016/j.molcel.2023.06.021. Epub 2023 Jul 13.
Mol Cell. 2023.
PMID: 37451262
Free article.
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