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Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs.
Erichsen MN, Hansen J, Ruiz JA, Demmer CS, Abrahamsen B, Bastlund JF, Bundgaard C, Jensen AA, Bunch L. Erichsen MN, et al. Among authors: demmer cs. Neurochem Res. 2014 Oct;39(10):1964-79. doi: 10.1007/s11064-014-1264-8. Epub 2014 Feb 28. Neurochem Res. 2014. PMID: 24682739
Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism.
Huynh TH, Demmer CS, Abrahamsen B, Marcher E, Frykman M, Jensen AA, Bunch L. Huynh TH, et al. Among authors: demmer cs. Springerplus. 2013 Mar 14;2:112. doi: 10.1186/2193-1801-2-112. eCollection 2013. Springerplus. 2013. PMID: 25530930 Free PMC article.
Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid.
Krogsgaard-Larsen N, Storgaard M, Møller C, Demmer CS, Hansen J, Han L, Monrad RN, Nielsen B, Tapken D, Pickering DS, Kastrup JS, Frydenvang K, Bunch L. Krogsgaard-Larsen N, et al. Among authors: demmer cs. J Med Chem. 2015 Aug 13;58(15):6131-50. doi: 10.1021/acs.jmedchem.5b00750. Epub 2015 Jul 22. J Med Chem. 2015. PMID: 26200741