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Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs.
Erichsen MN, Hansen J, Ruiz JA, Demmer CS, Abrahamsen B, Bastlund JF, Bundgaard C, Jensen AA, Bunch L. Erichsen MN, et al. Among authors: bastlund jf. Neurochem Res. 2014 Oct;39(10):1964-79. doi: 10.1007/s11064-014-1264-8. Epub 2014 Feb 28. Neurochem Res. 2014. PMID: 24682739
Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101).
Erichsen MN, Huynh TH, Abrahamsen B, Bastlund JF, Bundgaard C, Monrad O, Bekker-Jensen A, Nielsen CW, Frydenvang K, Jensen AA, Bunch L. Erichsen MN, et al. Among authors: bastlund jf. J Med Chem. 2010 Oct 14;53(19):7180-91. doi: 10.1021/jm1009154. J Med Chem. 2010. PMID: 20857912
Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration.
Eskildsen J, Redrobe JP, Sams AG, Dekermendjian K, Laursen M, Boll JB, Papke RL, Bundgaard C, Frederiksen K, Bastlund JF. Eskildsen J, et al. Among authors: bastlund jf. Bioorg Med Chem Lett. 2014 Jan 1;24(1):288-93. doi: 10.1016/j.bmcl.2013.11.022. Epub 2013 Nov 20. Bioorg Med Chem Lett. 2014. PMID: 24291041
In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia.
Redrobe JP, Jørgensen M, Christoffersen CT, Montezinho LP, Bastlund JF, Carnerup M, Bundgaard C, Lerdrup L, Plath N. Redrobe JP, et al. Among authors: bastlund jf. Psychopharmacology (Berl). 2014 Aug;231(16):3151-67. doi: 10.1007/s00213-014-3492-7. Epub 2014 Mar 1. Psychopharmacology (Berl). 2014. PMID: 24577516
A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude).
Hammer H, Bader BM, Ehnert C, Bundgaard C, Bunch L, Hoestgaard-Jensen K, Schroeder OH, Bastlund JF, Gramowski-Voß A, Jensen AA. Hammer H, et al. Among authors: bastlund jf. Mol Pharmacol. 2015 Aug;88(2):401-20. doi: 10.1124/mol.115.099291. Epub 2015 Jun 8. Mol Pharmacol. 2015. PMID: 26056160 Free PMC article.
Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH-102.
Haym I, Huynh TH, Hansen SW, Pedersen MH, Ruiz JA, Erichsen MN, Gynther M, Bjørn-Yoshimoto WE, Abrahamsen B, Bastlund JF, Bundgaard C, Eriksen AL, Jensen AA, Bunch L. Haym I, et al. Among authors: bastlund jf. ChemMedChem. 2016 Feb 17;11(4):403-19. doi: 10.1002/cmdc.201500527. Epub 2016 Jan 21. ChemMedChem. 2016. PMID: 26797816 Free article.
The 5-HT6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus.
Herrik KF, Mørk A, Richard N, Bundgaard C, Bastlund JF, de Jong IEM. Herrik KF, et al. Among authors: bastlund jf. Neuropharmacology. 2016 Aug;107:351-363. doi: 10.1016/j.neuropharm.2016.03.043. Epub 2016 Mar 31. Neuropharmacology. 2016. PMID: 27039041 Free article.
The 5-HT6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture.
Amat-Foraster M, Leiser SC, Herrik KF, Richard N, Agerskov C, Bundgaard C, Bastlund JF, de Jong IEM. Amat-Foraster M, et al. Among authors: bastlund jf. Neuropharmacology. 2017 Feb;113(Pt A):45-59. doi: 10.1016/j.neuropharm.2016.09.017. Epub 2016 Sep 16. Neuropharmacology. 2017. PMID: 27647493 Free article.
53 results