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A naturally occurring mutation K220T in the pleiotropic activator PrfA of Listeria monocytogenes results in a loss of virulence due to decreasing DNA-binding affinity.
Velge P, Herler M, Johansson J, Roche SM, Témoin S, Fedorov AA, Gracieux P, Almo SC, Goebel W, Cossart P. Velge P, et al. Among authors: gracieux p. Microbiology (Reading). 2007 Apr;153(Pt 4):995-1005. doi: 10.1099/mic.0.2006/002238-0. Microbiology (Reading). 2007. PMID: 17379709 Free article.
Investigation of specific substitutions in virulence genes characterizing phenotypic groups of low-virulence field strains of Listeria monocytogenes.
Roche SM, Gracieux P, Milohanic E, Albert I, Virlogeux-Payant I, Témoin S, Grépinet O, Kerouanton A, Jacquet C, Cossart P, Velge P. Roche SM, et al. Among authors: gracieux p. Appl Environ Microbiol. 2005 Oct;71(10):6039-48. doi: 10.1128/AEM.71.10.6039-6048.2005. Appl Environ Microbiol. 2005. PMID: 16204519 Free PMC article.
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