Rana S - Search Results

1

Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition.

Turajlic S, Furney SJ, Stamp G, Rana S, Ricken G, Oduko Y, Saturno G, Springer C, Hayes A, Gore M, Larkin J, Marais R. Turajlic S, et al. Among authors: rana s. Ann Oncol. 2014 May;25(5):959-67. doi: 10.1093/annonc/mdu049. Epub 2014 Feb 6. Ann Oncol. 2014. PMID: 24504448 Free PMC article.

2

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.

Garnett MJ, Rana S, Paterson H, Barford D, Marais R. Garnett MJ, et al. Among authors: rana s. Mol Cell. 2005 Dec 22;20(6):963-9. doi: 10.1016/j.molcel.2005.10.022. Mol Cell. 2005. PMID: 16364920 Free article.

3

Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.

Wellbrock C, Rana S, Paterson H, Pickersgill H, Brummelkamp T, Marais R. Wellbrock C, et al. Among authors: rana s. PLoS One. 2008 Jul 16;3(7):e2734. doi: 10.1371/journal.pone.0002734. PLoS One. 2008. PMID: 18628967 Free PMC article.

4

A novel, selective, and efficacious nanomolar pyridopyrazinone inhibitor of V600EBRAF.

Whittaker S, Ménard D, Kirk R, Ogilvie L, Hedley D, Zambon A, Lopes F, Preece N, Manne H, Rana S, Lambros M, Reis-Filho JS, Marais R, Springer CJ. Whittaker S, et al. Among authors: rana s. Cancer Res. 2010 Oct 15;70(20):8036-44. doi: 10.1158/0008-5472.CAN-10-1366. Epub 2010 Aug 31. Cancer Res. 2010. PMID: 20807807 Free PMC article.

5

Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia.

Packer LM, Rana S, Hayward R, O'Hare T, Eide CA, Rebocho A, Heidorn S, Zabriskie MS, Niculescu-Duvaz I, Druker BJ, Springer C, Marais R. Packer LM, et al. Among authors: rana s. Cancer Cell. 2011 Dec 13;20(6):715-27. doi: 10.1016/j.ccr.2011.11.004. Cancer Cell. 2011. PMID: 22169110 Free PMC article.

6

A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF^high /AXL^low melanoma.

Smith MP, Rana S, Ferguson J, Rowling EJ, Flaherty KT, Wargo JA, Marais R, Wellbrock C. Smith MP, et al. Among authors: rana s. Pigment Cell Melanoma Res. 2019 Mar;32(2):280-291. doi: 10.1111/pcmr.12741. Epub 2018 Oct 19. Pigment Cell Melanoma Res. 2019. PMID: 30277012 Free PMC article.

7

Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer.

Murillo MM, Rana S, Spencer-Dene B, Nye E, Stamp G, Downward J. Murillo MM, et al. Among authors: rana s. Cell Rep. 2018 Dec 26;25(13):3545-3553.e2. doi: 10.1016/j.celrep.2018.12.003. Cell Rep. 2018. PMID: 30590030 Free PMC article.

8

RAC1^P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance.

Lionarons DA, Hancock DC, Rana S, East P, Moore C, Murillo MM, Carvalho J, Spencer-Dene B, Herbert E, Stamp G, Damry D, Calado DP, Rosewell I, Fritsch R, Neubig RR, Molina-Arcas M, Downward J. Lionarons DA, et al. Among authors: rana s. Cancer Cell. 2019 Jul 8;36(1):68-83.e9. doi: 10.1016/j.ccell.2019.05.015. Epub 2019 Jun 27. Cancer Cell. 2019. PMID: 31257073 Free PMC article.

9

Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach.

Pender A, Garcia-Murillas I, Rana S, Cutts RJ, Kelly G, Fenwick K, Kozarewa I, Gonzalez de Castro D, Bhosle J, O'Brien M, Turner NC, Popat S, Downward J. Pender A, et al. Among authors: rana s. PLoS One. 2015 Sep 28;10(9):e0139074. doi: 10.1371/journal.pone.0139074. eCollection 2015. PLoS One. 2015. PMID: 26413866 Free PMC article.

10

Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer.

Molina-Arcas M, Moore C, Rana S, van Maldegem F, Mugarza E, Romero-Clavijo P, Herbert E, Horswell S, Li LS, Janes MR, Hancock DC, Downward J. Molina-Arcas M, et al. Among authors: rana s. Sci Transl Med. 2019 Sep 18;11(510):eaaw7999. doi: 10.1126/scitranslmed.aaw7999. Sci Transl Med. 2019. PMID: 31534020 Free PMC article.

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