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Optimal translational termination requires C4 lysyl hydroxylation of eRF1.
Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Münzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Trudgian DC, Schödel J, McCullagh JS, Ge W, Kessler BM, Gilbert RJ, Frolova LY, Alkalaeva E, Ratcliffe PJ, Schofield CJ, Coleman ML. Feng T, et al. Among authors: ratcliffe pj. Mol Cell. 2014 Feb 20;53(4):645-54. doi: 10.1016/j.molcel.2013.12.028. Epub 2014 Jan 30. Mol Cell. 2014. PMID: 24486019 Free PMC article.
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. Epstein AC, et al. Among authors: ratcliffe pj. Cell. 2001 Oct 5;107(1):43-54. doi: 10.1016/s0092-8674(01)00507-4. Cell. 2001. PMID: 11595184 Free article.
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. McNeill LA, et al. Among authors: ratcliffe pj. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-50. doi: 10.1016/s0960-894x(02)00219-6. Bioorg Med Chem Lett. 2002. PMID: 12039559
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ. Hewitson KS, et al. Among authors: ratcliffe pj. J Biol Chem. 2002 Jul 19;277(29):26351-5. doi: 10.1074/jbc.C200273200. Epub 2002 May 31. J Biol Chem. 2002. PMID: 12042299 Free article.
327 results