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Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Ataide MA, Andrade WA, Zamboni DS, Wang D, Souza Mdo C, Franklin BS, Elian S, Martins FS, Pereira D, Reed G, Fitzgerald KA, Golenbock DT, Gazzinelli RT. Ataide MA, et al. Among authors: franklin bs. PLoS Pathog. 2014 Jan;10(1):e1003885. doi: 10.1371/journal.ppat.1003885. Epub 2014 Jan 16. PLoS Pathog. 2014. PMID: 24453977 Free PMC article. Clinical Trial.
MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria.
Franklin BS, Rodrigues SO, Antonelli LR, Oliveira RV, Goncalves AM, Sales-Junior PA, Valente EP, Alvarez-Leite JI, Ropert C, Golenbock DT, Gazzinelli RT. Franklin BS, et al. Microbes Infect. 2007 Jun;9(7):881-90. doi: 10.1016/j.micinf.2007.03.007. Epub 2007 Mar 21. Microbes Infect. 2007. PMID: 17537666 Free article.
Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.
Franklin BS, Parroche P, Ataíde MA, Lauw F, Ropert C, de Oliveira RB, Pereira D, Tada MS, Nogueira P, da Silva LH, Bjorkbacka H, Golenbock DT, Gazzinelli RT. Franklin BS, et al. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5789-94. doi: 10.1073/pnas.0809742106. Epub 2009 Mar 18. Proc Natl Acad Sci U S A. 2009. PMID: 19297619 Free PMC article.
Soluble Uric Acid Activates the NLRP3 Inflammasome.
Braga TT, Forni MF, Correa-Costa M, Ramos RN, Barbuto JA, Branco P, Castoldi A, Hiyane MI, Davanso MR, Latz E, Franklin BS, Kowaltowski AJ, Camara NO. Braga TT, et al. Among authors: franklin bs. Sci Rep. 2017 Jan 13;7:39884. doi: 10.1038/srep39884. Sci Rep. 2017. PMID: 28084303 Free PMC article.
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease.
Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT. Venegas C, et al. Among authors: franklin bs. Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158. Nature. 2017. PMID: 29293211
Platelets Fuel the Inflammasome Activation of Innate Immune Cells.
Rolfes V, Ribeiro LS, Hawwari I, Böttcher L, Rosero N, Maasewerd S, Santos MLS, Próchnicki T, Silva CMS, Wanderley CWS, Rothe M, Schmidt SV, Stunden HJ, Bertheloot D, Rivas MN, Fontes CJ, Carvalho LH, Cunha FQ, Latz E, Arditi M, Franklin BS. Rolfes V, et al. Among authors: franklin bs. Cell Rep. 2020 May 12;31(6):107615. doi: 10.1016/j.celrep.2020.107615. Cell Rep. 2020. PMID: 32402278 Free PMC article.
Molecular basis of carrageenan-induced cytokines production in macrophages.
Lopes AH, Silva RL, Fonseca MD, Gomes FI, Maganin AG, Ribeiro LS, Marques LMM, Cunha FQ, Alves-Filho JC, Zamboni DS, Lopes NP, Franklin BS, Gombault A, Ramalho FS, Quesniaux VFJ, Couillin I, Ryffel B, Cunha TM. Lopes AH, et al. Among authors: franklin bs. Cell Commun Signal. 2020 Sep 7;18(1):141. doi: 10.1186/s12964-020-00621-x. Cell Commun Signal. 2020. PMID: 32894139 Free PMC article.
47 results