Berger Z - Search Results

1

Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons.

Li L, Nadanaciva S, Berger Z, Shen W, Paumier K, Schwartz J, Mou K, Loos P, Milici AJ, Dunlop J, Hirst WD. Li L, et al. Among authors: berger z. PLoS One. 2013 Dec 31;8(12):e85815. doi: 10.1371/journal.pone.0085815. eCollection 2013. PLoS One. 2013. PMID: 24392030 Free PMC article.

2

Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.

Paumier KL, Sukoff Rizzo SJ, Berger Z, Chen Y, Gonzales C, Kaftan E, Li L, Lotarski S, Monaghan M, Shen W, Stolyar P, Vasilyev D, Zaleska M, D Hirst W, Dunlop J. Paumier KL, et al. Among authors: berger z. PLoS One. 2013 Aug 1;8(8):e70274. doi: 10.1371/journal.pone.0070274. Print 2013. PLoS One. 2013. PMID: 23936403 Free PMC article.

3

Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons.

Shen W, Henry AG, Paumier KL, Li L, Mou K, Dunlop J, Berger Z, Hirst WD. Shen W, et al. Among authors: berger z. J Neurochem. 2014 Jun;129(5):884-94. doi: 10.1111/jnc.12672. Epub 2014 Mar 3. J Neurochem. 2014. PMID: 24494600 Free article.

4

Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates.

Berger Z, Perkins S, Ambroise C, Oborski C, Calabrese M, Noell S, Riddell D, Hirst WD. Berger Z, et al. PLoS One. 2015 Mar 12;10(3):e0119141. doi: 10.1371/journal.pone.0119141. eCollection 2015. PLoS One. 2015. PMID: 25763858 Free PMC article.

5

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.

Galatsis P, Henderson JL, Kormos BL, Han S, Kurumbail RG, Wager TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD. Galatsis P, et al. Among authors: berger z. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4132-40. doi: 10.1016/j.bmcl.2014.07.052. Epub 2014 Jul 30. Bioorg Med Chem Lett. 2014. PMID: 25113930

6

Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.

Henderson JL, Kormos BL, Hayward MM, Coffman KJ, Jasti J, Kurumbail RG, Wager TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD, Galatsis P. Henderson JL, et al. Among authors: berger z. J Med Chem. 2015 Jan 8;58(1):419-32. doi: 10.1021/jm5014055. Epub 2014 Nov 17. J Med Chem. 2015. PMID: 25353650

7

Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion.

Berger Z, Davies JE, Luo S, Pasco MY, Majoul I, O'Kane CJ, Rubinsztein DC. Berger Z, et al. Hum Mol Genet. 2006 Feb 1;15(3):453-65. doi: 10.1093/hmg/ddi460. Epub 2005 Dec 21. Hum Mol Genet. 2006. PMID: 16371423

8

Lithium induces autophagy by inhibiting inositol monophosphatase.

Sarkar S, Floto RA, Berger Z, Imarisio S, Cordenier A, Pasco M, Cook LJ, Rubinsztein DC. Sarkar S, et al. Among authors: berger z. J Cell Biol. 2005 Sep 26;170(7):1101-11. doi: 10.1083/jcb.200504035. J Cell Biol. 2005. PMID: 16186256 Free PMC article.

9

Rapamycin pre-treatment protects against apoptosis.

Ravikumar B, Berger Z, Vacher C, O'Kane CJ, Rubinsztein DC. Ravikumar B, et al. Among authors: berger z. Hum Mol Genet. 2006 Apr 1;15(7):1209-16. doi: 10.1093/hmg/ddl036. Epub 2006 Feb 23. Hum Mol Genet. 2006. PMID: 16497721

Hum. Mol. Genet., 11, 1107-1117, Ravikumar, B., Vacher, C., Berger, Z., Davies, J.E., Luo, S., Oroz, L.G., Scaravilli, F., Easton, D.F., Duden, R., O'Kane, C.J. et al. (2004) Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fl …

Hum. Mol. Genet., 11, 1107-1117, Ravikumar, B., Vacher, C., Berger, Z., Davies, J.E., Luo, S., Oroz, L.G., Scaravilli, F., Eas …

10

Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation.

Berger Z, Smith KA, Lavoie MJ. Berger Z, et al. Biochemistry. 2010 Jul 6;49(26):5511-23. doi: 10.1021/bi100157u. Biochemistry. 2010. PMID: 20515039 Free PMC article.

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