Ellens H - Search Results

1

Disposition and metabolism of darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in humans.

Dave M, Nash M, Young GC, Ellens H, Magee MH, Roberts AD, Taylor MA, Greenhill RW, Boyle GW. Dave M, et al. Among authors: ellens h. Drug Metab Dispos. 2014 Mar;42(3):415-30. doi: 10.1124/dmd.113.054486. Epub 2013 Dec 30. Drug Metab Dispos. 2014. PMID: 24378325 Clinical Trial.

2

Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.

Sakatis MZ, Reese MJ, Harrell AW, Taylor MA, Baines IA, Chen L, Bloomer JC, Yang EY, Ellens HM, Ambroso JL, Lovatt CA, Ayrton AD, Clarke SE. Sakatis MZ, et al. Chem Res Toxicol. 2012 Oct 15;25(10):2067-82. doi: 10.1021/tx300075j. Epub 2012 Sep 19. Chem Res Toxicol. 2012. PMID: 22931300

3

Prediction of the Transporter-Mediated Drug-Drug Interaction Potential of Dabrafenib and Its Major Circulating Metabolites.

Ellens H, Johnson M, Lawrence SK, Watson C, Chen L, Richards-Peterson LE. Ellens H, et al. Drug Metab Dispos. 2017 Jun;45(6):646-656. doi: 10.1124/dmd.116.073932. Epub 2017 Mar 20. Drug Metab Dispos. 2017. PMID: 28320730

4

Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions.

Ellens H, Deng S, Coleman J, Bentz J, Taub ME, Ragueneau-Majlessi I, Chung SP, Herédi-Szabó K, Neuhoff S, Palm J, Balimane P, Zhang L, Jamei M, Hanna I, O'Connor M, Bednarczyk D, Forsgard M, Chu X, Funk C, Guo A, Hillgren KM, Li L, Pak AY, Perloff ES, Rajaraman G, Salphati L, Taur JS, Weitz D, Wortelboer HM, Xia CQ, Xiao G, Yamagata T, Lee CA. Ellens H, et al. Drug Metab Dispos. 2013 Jul;41(7):1367-74. doi: 10.1124/dmd.112.050542. Epub 2013 Apr 25. Drug Metab Dispos. 2013. PMID: 23620486 Free PMC article.

5

Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin.

Johnson M, Patel D, Matheny C, Ho M, Chen L, Ellens H. Johnson M, et al. Among authors: ellens h. Drug Metab Dispos. 2017 Jan;45(1):27-34. doi: 10.1124/dmd.116.072397. Epub 2016 Oct 13. Drug Metab Dispos. 2017. PMID: 27737931

6

A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound.

Chen EP, Chen L, Ji Y, Tai G, Wen YH, Ellens H. Chen EP, et al. Among authors: ellens h. Drug Metab Dispos. 2010 Dec;38(12):2278-85. doi: 10.1124/dmd.110.034421. Epub 2010 Sep 15. Drug Metab Dispos. 2010. PMID: 20843940

7

Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.

Lee CA, O'Connor MA, Ritchie TK, Galetin A, Cook JA, Ragueneau-Majlessi I, Ellens H, Feng B, Taub ME, Paine MF, Polli JW, Ware JA, Zamek-Gliszczynski MJ. Lee CA, et al. Among authors: ellens h. Drug Metab Dispos. 2015 Apr;43(4):490-509. doi: 10.1124/dmd.114.062174. Epub 2015 Jan 13. Drug Metab Dispos. 2015. PMID: 25587128 Review.

8

Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.

Taub ME, Mease K, Sane RS, Watson CA, Chen L, Ellens H, Hirakawa B, Reyner EL, Jani M, Lee CA. Taub ME, et al. Among authors: ellens h. Drug Metab Dispos. 2011 Nov;39(11):2093-102. doi: 10.1124/dmd.111.040816. Epub 2011 Aug 17. Drug Metab Dispos. 2011. PMID: 21849517

9

Extrapolation of Elementary Rate Constants of P-glycoprotein-Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells.

Meng Z, Ellens H, Bentz J. Meng Z, et al. Among authors: ellens h. Drug Metab Dispos. 2017 Feb;45(2):190-197. doi: 10.1124/dmd.116.072140. Epub 2016 Nov 16. Drug Metab Dispos. 2017. PMID: 27856526

10

Derivation of a System-Independent K_i for P-glycoprotein Mediated Digoxin Transport from System-Dependent IC₅₀ Data.

Chaudhry A, Chung G, Lynn A, Yalvigi A, Brown C, Ellens H, O'Connor M, Lee C, Bentz J. Chaudhry A, et al. Among authors: ellens h. Drug Metab Dispos. 2018 Mar;46(3):279-290. doi: 10.1124/dmd.117.075606. Epub 2018 Jan 9. Drug Metab Dispos. 2018. PMID: 29317410

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