Abood ME - Search Results

1

Allosteric modulation of a cannabinoid G protein-coupled receptor: binding site elucidation and relationship to G protein signaling.

Shore DM, Baillie GL, Hurst DH, Navas F 3rd, Seltzman HH, Marcu JP, Abood ME, Ross RA, Reggio PH. Shore DM, et al. Among authors: abood me. J Biol Chem. 2014 Feb 28;289(9):5828-45. doi: 10.1074/jbc.M113.478495. Epub 2013 Dec 23. J Biol Chem. 2014. PMID: 24366865 Free PMC article.

2

Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.

Hurst D, Umejiego U, Lynch D, Seltzman H, Hyatt S, Roche M, McAllister S, Fleischer D, Kapur A, Abood M, Shi S, Jones J, Lewis D, Reggio P. Hurst D, et al. J Med Chem. 2006 Oct 5;49(20):5969-87. doi: 10.1021/jm060446b. J Med Chem. 2006. PMID: 17004712

3

Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55.

Kotsikorou E, Lynch DL, Abood ME, Reggio PH. Kotsikorou E, et al. Among authors: abood me. Chem Phys Lipids. 2011 Feb;164(2):131-43. doi: 10.1016/j.chemphyslip.2010.12.003. Epub 2010 Dec 24. Chem Phys Lipids. 2011. PMID: 21185816 Free PMC article.

4

Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy.

Garai S, Leo LM, Szczesniak AM, Hurst DP, Schaffer PC, Zagzoog A, Black T, Deschamps JR, Miess E, Schulz S, Janero DR, Straiker A, Pertwee RG, Abood ME, Kelly MEM, Reggio PH, Laprairie RB, Thakur GA. Garai S, et al. Among authors: abood me. J Med Chem. 2021 Jun 24;64(12):8104-8126. doi: 10.1021/acs.jmedchem.1c00040. Epub 2021 Apr 7. J Med Chem. 2021. PMID: 33826336

5

An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region.

McAllister SD, Rizvi G, Anavi-Goffer S, Hurst DP, Barnett-Norris J, Lynch DL, Reggio PH, Abood ME. McAllister SD, et al. Among authors: abood me. J Med Chem. 2003 Nov 20;46(24):5139-52. doi: 10.1021/jm0302647. J Med Chem. 2003. PMID: 14613317

6

Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation.

McAllister SD, Hurst DP, Barnett-Norris J, Lynch D, Reggio PH, Abood ME. McAllister SD, et al. Among authors: abood me. J Biol Chem. 2004 Nov 12;279(46):48024-37. doi: 10.1074/jbc.M406648200. Epub 2004 Aug 23. J Biol Chem. 2004. PMID: 15326174 Free article.

7

(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor.

Picone RP, Khanolkar AD, Xu W, Ayotte LA, Thakur GA, Hurst DP, Abood ME, Reggio PH, Fournier DJ, Makriyannis A. Picone RP, et al. Among authors: abood me. Mol Pharmacol. 2005 Dec;68(6):1623-35. doi: 10.1124/mol.105.014407. Epub 2005 Sep 12. Mol Pharmacol. 2005. PMID: 16157695

8

Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms.

Anavi-Goffer S, Fleischer D, Hurst DP, Lynch DL, Barnett-Norris J, Shi S, Lewis DL, Mukhopadhyay S, Howlett AC, Reggio PH, Abood ME. Anavi-Goffer S, et al. Among authors: abood me. J Biol Chem. 2007 Aug 24;282(34):25100-13. doi: 10.1074/jbc.M703388200. Epub 2007 Jun 26. J Biol Chem. 2007. PMID: 17595161 Free article.

9

Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands.

Kotsikorou E, Madrigal KE, Hurst DP, Sharir H, Lynch DL, Heynen-Genel S, Milan LB, Chung TD, Seltzman HH, Bai Y, Caron MG, Barak L, Abood ME, Reggio PH. Kotsikorou E, et al. Among authors: abood me. Biochemistry. 2011 Jun 28;50(25):5633-47. doi: 10.1021/bi200010k. Epub 2011 Jun 1. Biochemistry. 2011. PMID: 21534610 Free PMC article.

10

Cannabinoid receptors: nomenclature and pharmacological principles.

Console-Bram L, Marcu J, Abood ME. Console-Bram L, et al. Among authors: abood me. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jul 2;38(1):4-15. doi: 10.1016/j.pnpbp.2012.02.009. Epub 2012 Feb 28. Prog Neuropsychopharmacol Biol Psychiatry. 2012. PMID: 22421596 Free PMC article. Review.

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