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Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation.
Cell. 2013 Dec 5;155(6):1380-95. doi: 10.1016/j.cell.2013.11.016.
Cell. 2013.
PMID: 24315104
Free PMC article.
Differential H3K4 methylation identifies developmentally poised hematopoietic genes.
Orford K, Kharchenko P, Lai W, Dao MC, Worhunsky DJ, Ferro A, Janzen V, Park PJ, Scadden DT.
Orford K, et al.
Dev Cell. 2008 May;14(5):798-809. doi: 10.1016/j.devcel.2008.04.002.
Dev Cell. 2008.
PMID: 18477461
Free PMC article.
Item in Clipboard
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation.
Orford KW, Scadden DT.
Orford KW, et al.
Nat Rev Genet. 2008 Feb;9(2):115-28. doi: 10.1038/nrg2269.
Nat Rev Genet. 2008.
PMID: 18202695
Review.
Item in Clipboard
Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest.
Orford K, Orford CC, Byers SW.
Orford K, et al.
J Cell Biol. 1999 Aug 23;146(4):855-68. doi: 10.1083/jcb.146.4.855.
J Cell Biol. 1999.
PMID: 10459019
Free PMC article.
Item in Clipboard
Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin.
Orford K, Crockett C, Jensen JP, Weissman AM, Byers SW.
Orford K, et al.
J Biol Chem. 1997 Oct 3;272(40):24735-8. doi: 10.1074/jbc.272.40.24735.
J Biol Chem. 1997.
PMID: 9312064
Free article.
Item in Clipboard
Effects of low-fat and high-fat meals on steady-state pharmacokinetics of lapatinib in patients with advanced solid tumours.
Devriese LA, Koch KM, Mergui-Roelvink M, Matthys GM, Ma WW, Robidoux A, Stephenson JJ, Chu QS, Orford KW, Cartee L, Botbyl J, Arya N, Schellens JH.
Devriese LA, et al. Among authors: orford kw.
Invest New Drugs. 2014 Jun;32(3):481-8. doi: 10.1007/s10637-013-0055-4. Epub 2013 Dec 19.
Invest New Drugs. 2014.
PMID: 24346280
Clinical Trial.
Item in Clipboard
Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers.
Ho MY, Morris MJ, Pirhalla JL, Bauman JW, Pendry CB, Orford KW, Morrison RA, Cox DS.
Ho MY, et al. Among authors: orford kw.
Xenobiotica. 2014 Apr;44(4):352-68. doi: 10.3109/00498254.2013.831143. Epub 2013 Aug 23.
Xenobiotica. 2014.
PMID: 23971497
Clinical Trial.
Item in Clipboard
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