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Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.
Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT. Zhang J, et al. Among authors: varghese j. Sci Rep. 2016 Oct 26;6:35986. doi: 10.1038/srep35986. Sci Rep. 2016. PMID: 27782176 Free PMC article.
PAWS1 controls Wnt signalling through association with casein kinase 1α.
Bozatzi P, Dingwell KS, Wu KZ, Cooper F, Cummins TD, Hutchinson LD, Vogt J, Wood NT, Macartney TJ, Varghese J, Gourlay R, Campbell DG, Smith JC, Sapkota GP. Bozatzi P, et al. Among authors: varghese j. EMBO Rep. 2018 Apr;19(4):e44807. doi: 10.15252/embr.201744807. Epub 2018 Mar 7. EMBO Rep. 2018. PMID: 29514862 Free PMC article.
The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.
Fulcher LJ, Bozatzi P, Tachie-Menson T, Wu KZL, Cummins TD, Bufton JC, Pinkas DM, Dunbar K, Shrestha S, Wood NT, Weidlich S, Macartney TJ, Varghese J, Gourlay R, Campbell DG, Dingwell KS, Smith JC, Bullock AN, Sapkota GP. Fulcher LJ, et al. Among authors: varghese j. Sci Signal. 2018 May 22;11(531):eaao2341. doi: 10.1126/scisignal.aao2341. Sci Signal. 2018. PMID: 29789297 Free PMC article.
FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning.
Fulcher LJ, He Z, Mei L, Macartney TJ, Wood NT, Prescott AR, Whigham AJ, Varghese J, Gourlay R, Ball G, Clarke R, Campbell DG, Maxwell CA, Sapkota GP. Fulcher LJ, et al. Among authors: varghese j. EMBO Rep. 2019 Sep;20(9):e47495. doi: 10.15252/embr.201847495. Epub 2019 Jul 24. EMBO Rep. 2019. PMID: 31338967 Free PMC article.
Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling.
Bustos F, Segarra-Fas A, Nardocci G, Cassidy A, Antico O, Davidson L, Brandenburg L, Macartney TJ, Toth R, Hastie CJ, Moran J, Gourlay R, Varghese J, Soares RF, Montecino M, Findlay GM. Bustos F, et al. Among authors: varghese j. Dev Cell. 2020 Dec 7;55(5):629-647.e7. doi: 10.1016/j.devcel.2020.09.025. Epub 2020 Oct 19. Dev Cell. 2020. PMID: 33080171 Free PMC article.
Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription.
Blümli S, Wiechens N, Wu MY, Singh V, Gierlinski M, Schweikert G, Gilbert N, Naughton C, Sundaramoorthy R, Varghese J, Gourlay R, Soares R, Clark D, Owen-Hughes T. Blümli S, et al. Among authors: varghese j. Cell Rep. 2021 Nov 2;37(5):109943. doi: 10.1016/j.celrep.2021.109943. Cell Rep. 2021. PMID: 34731603 Free PMC article.
834 results