Gourlay R - Search Results

1

Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity.

Houde VP, Ritorto MS, Gourlay R, Varghese J, Davies P, Shpiro N, Sakamoto K, Alessi DR. Houde VP, et al. Among authors: gourlay r. Biochem J. 2014 Feb 15;458(1):41-56. doi: 10.1042/BJ20131324. Biochem J. 2014. PMID: 24295069 Free PMC article.

2

Identification of Protor as a novel Rictor-binding component of mTOR complex-2.

Pearce LR, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR. Pearce LR, et al. Among authors: gourlay r. Biochem J. 2007 Aug 1;405(3):513-22. doi: 10.1042/BJ20070540. Biochem J. 2007. PMID: 17461779 Free PMC article.

3

The role of TBK1 and IKKε in the expression and activation of Pellino 1.

Smith H, Liu XY, Dai L, Goh ET, Chan AT, Xi J, Seh CC, Qureshi IA, Lescar J, Ruedl C, Gourlay R, Morton S, Hough J, McIver EG, Cohen P, Cheung PC. Smith H, et al. Among authors: gourlay r. Biochem J. 2011 Mar 15;434(3):537-48. doi: 10.1042/BJ20101421. Biochem J. 2011. PMID: 21204785 Free PMC article.

4

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.

Filippi BM, de los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR. Filippi BM, et al. Among authors: gourlay r. EMBO J. 2011 May 4;30(9):1730-41. doi: 10.1038/emboj.2011.78. Epub 2011 Mar 18. EMBO J. 2011. PMID: 21423148 Free PMC article.

5

Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.

Gleason CE, Ordureau A, Gourlay R, Arthur JSC, Cohen P. Gleason CE, et al. Among authors: gourlay r. J Biol Chem. 2011 Oct 14;286(41):35663-35674. doi: 10.1074/jbc.M111.267567. Epub 2011 Aug 23. J Biol Chem. 2011. PMID: 21862579 Free PMC article.

6

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.

Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM. Kondapalli C, et al. Among authors: gourlay r. Open Biol. 2012 May;2(5):120080. doi: 10.1098/rsob.120080. Open Biol. 2012. PMID: 22724072 Free PMC article.

7

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J. de Los Heros P, et al. Among authors: gourlay r. Biochem J. 2014 Mar 15;458(3):559-73. doi: 10.1042/BJ20131478. Biochem J. 2014. PMID: 24393035 Free PMC article.

8

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction.

van der Wijst J, Blanchard MG, Woodroof HI, Macartney TJ, Gourlay R, Hoenderop JG, Bindels RJ, Alessi DR. van der Wijst J, et al. Among authors: gourlay r. Biochem J. 2014 Jun 1;460(2):165-75. doi: 10.1042/BJ20131639. Biochem J. 2014. PMID: 24650431 Free PMC article.

9

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, Ritorto MS, Hofmann K, Alessi DR, Knebel A, Trost M, Muqit MM. Kazlauskaite A, et al. Among authors: gourlay r. Biochem J. 2014 May 15;460(1):127-39. doi: 10.1042/BJ20140334. Biochem J. 2014. PMID: 24660806 Free PMC article.

10

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.

Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, Birnbaum MJ, Sutherland C, Sakamoto K. Patel K, et al. Among authors: gourlay r. Nat Commun. 2014 Aug 4;5:4535. doi: 10.1038/ncomms5535. Nat Commun. 2014. PMID: 25088745 Free PMC article.

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