McFarlane C - Search Results

1

The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.

McFarlane C, McFarlane S, Paul I, Arthur K, Scheaff M, Kerr K, Stevenson M, Fennell DA, Johnston JA. McFarlane C, et al. Among authors: mcfarlane s. Oncotarget. 2013 Oct;4(10):1836-43. doi: 10.18632/oncotarget.1282. Oncotarget. 2013. PMID: 24123619 Free PMC article.

2

USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor.

Jaworski J, de la Vega M, Fletcher SJ, McFarlane C, Greene MK, Smyth AW, Van Schaeybroeck S, Johnston JA, Scott CJ, Rappoport JZ, Burrows JF. Jaworski J, et al. Among authors: mcfarlane c. Oncotarget. 2014 Aug 30;5(16):6964-75. doi: 10.18632/oncotarget.2165. Oncotarget. 2014. PMID: 25026282 Free PMC article.

3

CD44 increases the efficiency of distant metastasis of breast cancer.

McFarlane S, Coulter JA, Tibbits P, O'Grady A, McFarlane C, Montgomery N, Hill A, McCarthy HO, Young LS, Kay EW, Isacke CM, Waugh DJ. McFarlane S, et al. Among authors: mcfarlane c. Oncotarget. 2015 May 10;6(13):11465-76. doi: 10.18632/oncotarget.3410. Oncotarget. 2015. PMID: 25888636 Free PMC article.

4

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

de la Vega M, Burrows JF, McFarlane C, Govender U, Scott CJ, Johnston JA. de la Vega M, et al. Among authors: mcfarlane c. J Biol Chem. 2010 Apr 16;285(16):12028-36. doi: 10.1074/jbc.M109.081448. Epub 2010 Feb 10. J Biol Chem. 2010. PMID: 20147298 Free PMC article.

5

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

McFarlane C, Kelvin AA, de la Vega M, Govender U, Scott CJ, Burrows JF, Johnston JA. McFarlane C, et al. Cancer Res. 2010 Apr 15;70(8):3329-39. doi: 10.1158/0008-5472.CAN-09-4152. Epub 2010 Apr 13. Cancer Res. 2010. PMID: 20388806

6

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

de la Vega M, Kelvin AA, Dunican DJ, McFarlane C, Burrows JF, Jaworski J, Stevenson NJ, Dib K, Rappoport JZ, Scott CJ, Long A, Johnston JA. de la Vega M, et al. Among authors: mcfarlane c. Nat Commun. 2011 Mar 29;2:259. doi: 10.1038/ncomms1243. Nat Commun. 2011. PMID: 21448158 Free PMC article.

7

A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17.

Jaworski J, Govender U, McFarlane C, de la Vega M, Greene MK, Rawlings ND, Johnston JA, Scott CJ, Burrows JF. Jaworski J, et al. Among authors: mcfarlane c. Biochem J. 2014 Jan 15;457(2):289-300. doi: 10.1042/BJ20131213. Biochem J. 2014. PMID: 24134311 Free article.

8

CD44-mediated activation of α5β1-integrin, cortactin and paxillin signaling underpins adhesion of basal-like breast cancer cells to endothelium and fibronectin-enriched matrices.

McFarlane S, McFarlane C, Montgomery N, Hill A, Waugh DJ. McFarlane S, et al. Among authors: mcfarlane c. Oncotarget. 2015 Nov 3;6(34):36762-73. doi: 10.18632/oncotarget.5461. Oncotarget. 2015. PMID: 26447611 Free PMC article.

9

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

Burrows JF, Kelvin AA, McFarlane C, Burden RE, McGrattan MJ, De la Vega M, Govender U, Quinn DJ, Dib K, Gadina M, Scott CJ, Johnston JA. Burrows JF, et al. Among authors: mcfarlane c. J Biol Chem. 2009 Apr 3;284(14):9587-95. doi: 10.1074/jbc.M807216200. Epub 2009 Feb 2. J Biol Chem. 2009. PMID: 19188362 Free PMC article.

10

Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization.

Small DM, Burden RE, Jaworski J, Hegarty SM, Spence S, Burrows JF, McFarlane C, Kissenpfennig A, McCarthy HO, Johnston JA, Walker B, Scott CJ. Small DM, et al. Among authors: mcfarlane c. Int J Cancer. 2013 Nov;133(9):2102-12. doi: 10.1002/ijc.28238. Epub 2013 May 29. Int J Cancer. 2013. PMID: 23629809 Free article.

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