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Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Chang YS, Graves B, Guerlavais V, Tovar C, Packman K, To KH, Olson KA, Kesavan K, Gangurde P, Mukherjee A, Baker T, Darlak K, Elkin C, Filipovic Z, Qureshi FZ, Cai H, Berry P, Feyfant E, Shi XE, Horstick J, Annis DA, Manning AM, Fotouhi N, Nash H, Vassilev LT, Sawyer TK. Chang YS, et al. Among authors: feyfant e. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3445-54. doi: 10.1073/pnas.1303002110. Epub 2013 Aug 14. Proc Natl Acad Sci U S A. 2013. PMID: 23946421 Free PMC article.
A general approach to site-specific antibody drug conjugates.
Tian F, Lu Y, Manibusan A, Sellers A, Tran H, Sun Y, Phuong T, Barnett R, Hehli B, Song F, DeGuzman MJ, Ensari S, Pinkstaff JK, Sullivan LM, Biroc SL, Cho H, Schultz PG, DiJoseph J, Dougher M, Ma D, Dushin R, Leal M, Tchistiakova L, Feyfant E, Gerber HP, Sapra P. Tian F, et al. Among authors: feyfant e. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1766-71. doi: 10.1073/pnas.1321237111. Epub 2014 Jan 17. Proc Natl Acad Sci U S A. 2014. PMID: 24443552 Free PMC article.
Fragment-based drug design.
Feyfant E, Cross JB, Paris K, Tsao DH. Feyfant E, et al. Methods Mol Biol. 2011;685:241-52. doi: 10.1007/978-1-60761-931-4_12. Methods Mol Biol. 2011. PMID: 20981527
Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Hughes DJ, Tiede C, Penswick N, Tang AA, Trinh CH, Mandal U, Zajac KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC, Whitehouse A. Hughes DJ, et al. Among authors: feyfant e. Sci Signal. 2017 Nov 14;10(505):eaaj2005. doi: 10.1126/scisignal.aaj2005. Sci Signal. 2017. PMID: 29138295 Free PMC article.
Modeling mutations in protein structures.
Feyfant E, Sali A, Fiser A. Feyfant E, et al. Protein Sci. 2007 Sep;16(9):2030-41. doi: 10.1110/ps.072855507. Protein Sci. 2007. PMID: 17766392 Free PMC article.
Lead optimization via high-throughput molecular docking.
Joseph-McCarthy D, Baber JC, Feyfant E, Thompson DC, Humblet C. Joseph-McCarthy D, et al. Among authors: feyfant e. Curr Opin Drug Discov Devel. 2007 May;10(3):264-74. Curr Opin Drug Discov Devel. 2007. PMID: 17554852 Review.
CONFIRM: connecting fragments found in receptor molecules.
Thompson DC, Denny RA, Nilakantan R, Humblet C, Joseph-McCarthy D, Feyfant E. Thompson DC, et al. Among authors: feyfant e. J Comput Aided Mol Des. 2008 Oct;22(10):761-72. doi: 10.1007/s10822-008-9221-8. Epub 2008 Jul 9. J Comput Aided Mol Des. 2008. PMID: 18612831
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.
Hopper DW, Vera MD, How D, Sabatini J, Xiang JS, Ipek M, Thomason J, Hu Y, Feyfant E, Wang Q, Georgiadis KE, Reifenberg E, Sheldon RT, Keohan CC, Majumdar MK, Morris EA, Skotnicki J, Sum PE. Hopper DW, et al. Among authors: feyfant e. Bioorg Med Chem Lett. 2009 May 1;19(9):2487-91. doi: 10.1016/j.bmcl.2009.03.056. Epub 2009 Mar 18. Bioorg Med Chem Lett. 2009. PMID: 19329309
22 results