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Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics.
Pauli I, Rezende CO Jr, Slafer BW, Dessoy MA, de Souza ML, Ferreira LLG, Adjanohun ALM, Ferreira RS, Magalhães LG, Krogh R, Michelan-Duarte S, Del Pintor RV, da Silva FBR, Cruz FC, Dias LC, Andricopulo AD. Pauli I, et al. Among authors: rezende co jr. Front Pharmacol. 2022 Jan 5;12:774069. doi: 10.3389/fphar.2021.774069. eCollection 2021. Front Pharmacol. 2022. PMID: 35069198 Free PMC article.
Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity.
Ferreira RAA, Pauli I, Sampaio TS, de Souza ML, Ferreira LLG, Magalhães LG, Rezende CO Jr, Ferreira RS, Krogh R, Dias LC, Andricopulo AD. Ferreira RAA, et al. Among authors: rezende co jr. Front Chem. 2019 Nov 25;7:798. doi: 10.3389/fchem.2019.00798. eCollection 2019. Front Chem. 2019. PMID: 31824926 Free PMC article.
Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer.
Chantarasriwong O, Milcarek AT, Morales TH, Settle AL, Rezende CO Jr, Althufairi BD, Theodoraki MA, Alpaugh ML, Theodorakis EA. Chantarasriwong O, et al. Among authors: rezende co jr. Eur J Med Chem. 2019 Apr 15;168:405-413. doi: 10.1016/j.ejmech.2019.02.047. Epub 2019 Feb 20. Eur J Med Chem. 2019. PMID: 30831408