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Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.
Sheldrake HM, Travica S, Johansson I, Loadman PM, Sutherland M, Elsalem L, Illingworth N, Cresswell AJ, Reuillon T, Shnyder SD, Mkrtchian S, Searcey M, Ingelman-Sundberg M, Patterson LH, Pors K. Sheldrake HM, et al. Among authors: patterson lh. J Med Chem. 2013 Aug 8;56(15):6273-7. doi: 10.1021/jm4000209. Epub 2013 Jul 26. J Med Chem. 2013. PMID: 23844629 Free article.
Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.
Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH. Sutherland M, et al. Among authors: patterson lh. Mol Cancer Ther. 2013 Jan;12(1):27-37. doi: 10.1158/1535-7163.MCT-12-0405. Epub 2012 Oct 1. Mol Cancer Ther. 2013. PMID: 23033491
Resistance in cancer: a target for drug discovery.
Searcey M, Patterson LH. Searcey M, et al. Among authors: patterson lh. Curr Med Chem Anticancer Agents. 2004 Sep;4(5):457-60. doi: 10.2174/1568011043352722. Curr Med Chem Anticancer Agents. 2004. PMID: 15379703 Review.
Truncated azinomycin analogues intercalate into DNA.
Casely-Hayford MA, Pors K, Patterson LH, Gerner C, Neidle S, Searcey M. Casely-Hayford MA, et al. Among authors: patterson lh. Bioorg Med Chem Lett. 2005 Feb 1;15(3):653-6. doi: 10.1016/j.bmcl.2004.11.037. Bioorg Med Chem Lett. 2005. PMID: 15664831
Use of the hollow fiber assay for the evaluation of DNA damaging agents.
Veiga JP, Cooper PA, Pors K, Patterson LH, Bibby MC, Shnyder SD. Veiga JP, et al. Among authors: patterson lh. J Pharmacol Toxicol Methods. 2011 Nov-Dec;64(3):226-32. doi: 10.1016/j.vascn.2011.04.006. Epub 2011 Apr 30. J Pharmacol Toxicol Methods. 2011. PMID: 21569858
121 results