Ruggeri BA - Search Results

1

Animal models of disease: pre-clinical animal models of cancer and their applications and utility in drug discovery.

Ruggeri BA, Camp F, Miknyoczki S. Ruggeri BA, et al. Biochem Pharmacol. 2014 Jan 1;87(1):150-61. doi: 10.1016/j.bcp.2013.06.020. Epub 2013 Jun 28. Biochem Pharmacol. 2014. PMID: 23817077 Review.

2

Animal models of human disease: challenges in enabling translation.

McGonigle P, Ruggeri B. McGonigle P, et al. Biochem Pharmacol. 2014 Jan 1;87(1):162-71. doi: 10.1016/j.bcp.2013.08.006. Epub 2013 Aug 14. Biochem Pharmacol. 2014. PMID: 23954708 Review.

3

Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): a novel oncology therapeutic agent.

Hudkins RL, Becknell NC, Zulli AL, Underiner TL, Angeles TS, Aimone LD, Albom MS, Chang H, Miknyoczki SJ, Hunter K, Jones-Bolin S, Zhao H, Bacon ER, Mallamo JP, Ator MA, Ruggeri BA. Hudkins RL, et al. Among authors: ruggeri ba. J Med Chem. 2012 Jan 26;55(2):903-13. doi: 10.1021/jm201449n. Epub 2012 Jan 6. J Med Chem. 2012. PMID: 22148921

4

The Trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma.

Miknyoczki SJ, Chang H, Klein-Szanto A, Dionne CA, Ruggeri BA. Miknyoczki SJ, et al. Among authors: ruggeri ba. Clin Cancer Res. 1999 Aug;5(8):2205-12. Clin Cancer Res. 1999. PMID: 10473107

5

Role of neurotrophin-trk interactions in oncology: the anti-tumor efficacy of potent and selective trk tyrosine kinase inhibitors in pre-clinical tumor models.

Ruggeri BA, Miknyoczki SJ, Singh J, Hudkins RL. Ruggeri BA, et al. Curr Med Chem. 1999 Sep;6(9):845-57. Curr Med Chem. 1999. PMID: 10495355 Review.

6

The neurotrophin-trk receptor axes are critical for the growth and progression of human prostatic carcinoma and pancreatic ductal adenocarcinoma xenografts in nude mice.

Miknyoczki SJ, Wan W, Chang H, Dobrzanski P, Ruggeri BA, Dionne CA, Buchkovich K. Miknyoczki SJ, et al. Among authors: ruggeri ba. Clin Cancer Res. 2002 Jun;8(6):1924-31. Clin Cancer Res. 2002. PMID: 12060637

7

Design and synthesis of dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases.

Dandu R, Zulli AL, Bacon ER, Underiner T, Robinson C, Chang H, Miknyoczki S, Grobelny J, Ruggeri BA, Yang S, Albom MS, Angeles TS, Aimone LD, Hudkins RL. Dandu R, et al. Among authors: ruggeri ba. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1916-21. doi: 10.1016/j.bmcl.2008.02.001. Epub 2008 Feb 7. Bioorg Med Chem Lett. 2008. PMID: 18308565

8

Neurotrophin-Trk receptor interactions in neoplasia: a possible role in interstitial and perineural invasion in ductal pancreatic cancer.

Miknyoczki SJ, Klein-Szanto AJ, Ruggeri BA. Miknyoczki SJ, et al. Among authors: ruggeri ba. Crit Rev Oncog. 1996;7(1-2):89-100. doi: 10.1615/critrevoncog.v7.i1-2.60. Crit Rev Oncog. 1996. PMID: 9109499 Review.

9

The novel Trk receptor tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits antitumor efficacy against human pancreatic carcinoma (Panc1) xenograft growth and in vivo invasiveness.

Miknyoczki SJ, Dionne CA, Klein-Szanto AJ, Ruggeri BA. Miknyoczki SJ, et al. Among authors: ruggeri ba. Ann N Y Acad Sci. 1999 Jun 30;880:252-62. doi: 10.1111/j.1749-6632.1999.tb09530.x. Ann N Y Acad Sci. 1999. PMID: 10415871

10

Chemopreventive activity of Oltipraz against N-nitrosobis(2-oxopropyl)amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters.

Clapper ML, Wood M, Leahy K, Lang D, Miknyoczki S, Ruggeri BA. Clapper ML, et al. Among authors: ruggeri ba. Carcinogenesis. 1995 Sep;16(9):2159-65. doi: 10.1093/carcin/16.9.2159. Carcinogenesis. 1995. PMID: 7554069

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