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Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.
Elife. 2023 Sep 22;12:e85023. doi: 10.7554/eLife.85023.
Elife. 2023.
PMID: 37737220
Free PMC article.
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.
Summers RL, Pasaje CFA, Pisco JP, Striepen J, Luth MR, Kumpornsin K, Carpenter EF, Munro JT, Lin D, Plater A, Punekar AS, Shepherd AM, Shepherd SM, Vanaerschot M, Murithi JM, Rubiano K, Akidil A, Ottilie S, Mittal N, Dilmore AH, Won M, Mandt REK, McGowen K, Owen E, Walpole C, Llinás M, Lee MCS, Winzeler EA, Fidock DA, Gilbert IH, Wirth DF, Niles JC, Baragaña B, Lukens AK.
Summers RL, et al. Among authors: mandt rek.
Cell Chem Biol. 2022 Feb 17;29(2):191-201.e8. doi: 10.1016/j.chembiol.2021.07.010. Epub 2021 Aug 3.
Cell Chem Biol. 2022.
PMID: 34348113
Free PMC article.
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In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.
Mandt REK, Lafuente-Monasterio MJ, Sakata-Kato T, Luth MR, Segura D, Pablos-Tanarro A, Viera S, Magan N, Ottilie S, Winzeler EA, Lukens AK, Gamo FJ, Wirth DF.
Mandt REK, et al.
Sci Transl Med. 2019 Dec 4;11(521):eaav1636. doi: 10.1126/scitranslmed.aav1636.
Sci Transl Med. 2019.
PMID: 31801884
Free PMC article.
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Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum.
Ross LS, Lafuente-Monasterio MJ, Sakata-Kato T, Mandt REK, Gamo FJ, Wirth DF, Lukens AK.
Ross LS, et al. Among authors: mandt rek.
ACS Infect Dis. 2018 Apr 13;4(4):508-515. doi: 10.1021/acsinfecdis.7b00217. Epub 2018 Jan 22.
ACS Infect Dis. 2018.
PMID: 29336544
Free PMC article.
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Heterochromatin Protein 1a (HP1a) partner specificity is determined by critical amino acids in the chromo shadow domain and C-terminal extension.
Mendez DL, Mandt RE, Elgin SC.
Mendez DL, et al. Among authors: mandt re.
J Biol Chem. 2013 Aug 2;288(31):22315-23. doi: 10.1074/jbc.M113.468413. Epub 2013 Jun 23.
J Biol Chem. 2013.
PMID: 23793104
Free PMC article.
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