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Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers.
Tong G, Wang JS, Sverdlov O, Huang SP, Slemmon R, Croop R, Castaneda L, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Dockens RC. Tong G, et al. Among authors: gu h. Clin Ther. 2012 Mar;34(3):654-67. doi: 10.1016/j.clinthera.2012.01.022. Epub 2012 Feb 28. Clin Ther. 2012. PMID: 22381714 Clinical Trial.
A contrast in safety, pharmacokinetics and pharmacodynamics across age groups after a single 50 mg oral dose of the γ-secretase inhibitor avagacestat.
Tong G, Wang JS, Sverdlov O, Huang SP, Slemmon R, Croop R, Castaneda L, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Dockens R. Tong G, et al. Among authors: gu h. Br J Clin Pharmacol. 2013 Jan;75(1):136-45. doi: 10.1111/j.1365-2125.2012.04339.x. Br J Clin Pharmacol. 2013. PMID: 22616739 Free PMC article.
A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects.
Dockens R, Wang JS, Castaneda L, Sverdlov O, Huang SP, Slemmon R, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Tong G. Dockens R, et al. Among authors: gu h. Clin Pharmacokinet. 2012 Oct 1;51(10):681-93. doi: 10.1007/s40262-012-0005-x. Clin Pharmacokinet. 2012. PMID: 23018531 Clinical Trial.
Development and validation of sensitive and selective LC-MS/MS methods for the determination of BMS-708163, a gamma-secretase inhibitor, in plasma and cerebrospinal fluid using deprotonated or formate adduct ions as precursor ions.
Gu H, Deng Y, Wang J, Aubry AF, Arnold ME. Gu H, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2319-26. doi: 10.1016/j.jchromb.2010.06.041. Epub 2010 Jul 6. J Chromatogr B Analyt Technol Biomed Life Sci. 2010. PMID: 20674522
Role of regional absorption and gastrointestinal motility on variability in oral absorption of a model drug.
Narang AS, Balakrishnan A, Morrison J, Li J, Wang J, Gu H, Taylor K, Santone K, Ehrmann J, Beyer S, Lu X, Ketner R, Pizzano J, Orcutt T, Shields E, Dulac H, Aborn S, Batchelder M, Lentz K. Narang AS, et al. Among authors: gu h. Eur J Pharm Biopharm. 2017 Aug;117:333-345. doi: 10.1016/j.ejpb.2017.04.026. Epub 2017 Apr 25. Eur J Pharm Biopharm. 2017. PMID: 28455207
Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.
Jiang H, Zeng J, Li W, Bifano M, Gu H, Titsch C, Easter J, Burrell R, Kandoussi H, Aubry AF, Arnold ME. Jiang H, et al. Among authors: gu h. Anal Chem. 2012 Nov 20;84(22):10031-7. doi: 10.1021/ac3024558. Epub 2012 Nov 6. Anal Chem. 2012. PMID: 23106420
Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon-γ-Induced Protein 10, BMS-986184, in Healthy Participants to Guide Therapeutic Dosing.
Cai W, Leil TA, Gibiansky L, Krishna M, Zhang H, Gu H, Sun H, Throup J, Banerjee S, Girgis I. Cai W, et al. Among authors: gu h. Clin Pharmacol Drug Dev. 2020 Aug;9(6):689-698. doi: 10.1002/cpdd.784. Epub 2020 Feb 18. Clin Pharmacol Drug Dev. 2020. PMID: 32068354 Free PMC article. Clinical Trial.
Liquid chromatography and tandem mass spectrometry method for the quantitative determination of saxagliptin and its major pharmacologically active 5-monohydroxy metabolite in human plasma: method validation and overcoming specific and non-specific binding at low concentrations.
Xu XS, Demers R, Gu H, Christopher LJ, Su H, Cojocaru L, Boulton DW, Kirby M, Stouffer B, Humphreys WG, Arnold ME. Xu XS, et al. Among authors: gu h. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 15;889-890:77-86. doi: 10.1016/j.jchromb.2012.01.033. Epub 2012 Feb 6. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 22349123
6,247 results