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Interleukin-22 is frequently expressed in small- and large-cell lung cancer and promotes growth in chemotherapy-resistant cancer cells.
Kobold S, Völk S, Clauditz T, Küpper NJ, Minner S, Tufman A, Düwell P, Lindner M, Koch I, Heidegger S, Rothenfuer S, Schnurr M, Huber RM, Wilczak W, Endres S. Kobold S, et al. Among authors: duwell p. J Thorac Oncol. 2013 Aug;8(8):1032-42. doi: 10.1097/JTO.0b013e31829923c8. J Thorac Oncol. 2013. PMID: 23774470 Free article.
Innate Immune Stimulation in Cancer Therapy.
Düwell P, Heidegger S, Kobold S. Düwell P, et al. Hematol Oncol Clin North Am. 2019 Apr;33(2):215-231. doi: 10.1016/j.hoc.2018.12.002. Epub 2019 Jan 9. Hematol Oncol Clin North Am. 2019. PMID: 30832996 Review.
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
Bittner ZA, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, Herster F, Cardona Gloria Y, Chang TH, Bork F, Greve CL, Löffler MW, Wolz OO, Schilling NA, Kümmerle-Deschner JB, Wagner S, Delor A, Grimbacher B, Hantschel O, Scharl M, Wu H, Latz E, Weber ANR. Bittner ZA, et al. Among authors: duwell p. J Exp Med. 2021 Nov 1;218(11):e20201656. doi: 10.1084/jem.20201656. Epub 2021 Sep 23. J Exp Med. 2021. PMID: 34554188 Free PMC article.