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The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.
Loregger A, Grandl M, Mejías-Luque R, Allgäuer M, Degenhart K, Haselmann V, Oikonomou C, Hatzis P, Janssen KP, Nitsche U, Gradl D, van den Broek O, Destree O, Ulm K, Neumaier M, Kalali B, Jung A, Varela I, Schmid RM, Rad R, Busch DH, Gerhard M. Loregger A, et al. Among authors: janssen kp. Sci Signal. 2015 Sep 8;8(393):ra90. doi: 10.1126/scisignal.aac6757. Sci Signal. 2015. PMID: 26350900
PPARγ-activation increases intestinal M1 macrophages and mitigates formation of serrated adenomas in mutant KRAS mice.
Gutting T, Weber CA, Weidner P, Herweck F, Henn S, Friedrich T, Yin S, Kzhyshkowska J, Gaiser T, Janssen KP, Reindl W, Ebert MPA, Burgermeister E. Gutting T, et al. Among authors: janssen kp. Oncoimmunology. 2018 Feb 1;7(5):e1423168. doi: 10.1080/2162402X.2017.1423168. eCollection 2018. Oncoimmunology. 2018. PMID: 29721374 Free PMC article.
BarrettNET-a prospective registry for risk estimation of patients with Barrett's esophagus to progress to adenocarcinoma.
Wiethaler M, Slotta-Huspenina J, Brandtner A, Horstmann J, Wein F, Baumeister T, Radani N, Gerland S, Anand A, Lange S, Schmidt M, Janssen KP, Conrad A, Johannes W, Strauch K, Quante AS, Linkohr B, Kuhn KA, Blaser R, Lehmann A, Kohlmayer F, Weichert W, Schmid RM, Becker KF, Quante M. Wiethaler M, et al. Among authors: janssen kp. Dis Esophagus. 2019 Aug 1;32(8):doz024. doi: 10.1093/dote/doz024. Dis Esophagus. 2019. PMID: 31329831
Wild-type APC Influences the Severity of Familial Adenomatous Polyposis.
Flisikowski K, Perleberg C, Niu G, Winogrodzki T, Bak A, Liang W, Grodziecki A, Zhang Y, Pausch H, Flisikowska T, Klinger B, Perkowska A, Kind A, Switonski M, Janssen KP, Saur D, Schnieke A. Flisikowski K, et al. Among authors: janssen kp. Cell Mol Gastroenterol Hepatol. 2022;13(2):669-671.e3. doi: 10.1016/j.jcmgh.2021.11.002. Epub 2021 Nov 10. Cell Mol Gastroenterol Hepatol. 2022. PMID: 34774804 Free PMC article. No abstract available.
Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19.
Schult D, Reitmeier S, Koyumdzhieva P, Lahmer T, Middelhoff M, Erber J, Schneider J, Kager J, Frolova M, Horstmann J, Fricke L, Steiger K, Jesinghaus M, Janssen KP, Protzer U, Neuhaus K, Schmid RM, Haller D, Quante M. Schult D, et al. Among authors: janssen kp. Gut Microbes. 2022 Jan-Dec;14(1):2031840. doi: 10.1080/19490976.2022.2031840. Gut Microbes. 2022. PMID: 35174781 Free PMC article.
A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.
Buchert M, Rohde F, Eissmann M, Tebbutt N, Williams B, Tan CW, Owen A, Hirokawa Y, Gnann A, Orend G, Orner G, Dashwood RH, Heath JK, Ernst M, Janssen KP. Buchert M, et al. Among authors: janssen kp. Dis Model Mech. 2015 Nov;8(11):1361-73. doi: 10.1242/dmm.019844. Epub 2015 Aug 6. Dis Model Mech. 2015. PMID: 26398937 Free PMC article.
193 results