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Vaccination using recombinants influenza and adenoviruses encoding amastigote surface protein-2 are highly effective on protection against Trypanosoma cruzi infection.
Barbosa RP, Filho BG, Dos Santos LI, Junior PA, Marques PE, Pereira RV, Cara DC, Bruña-Romero O, Rodrigues MM, Gazzinelli RT, Machado AV. Barbosa RP, et al. Among authors: rodrigues mm. PLoS One. 2013 Apr 24;8(4):e61795. doi: 10.1371/journal.pone.0061795. Print 2013. PLoS One. 2013. PMID: 23637908 Free PMC article.
A human type 5 adenovirus-based Trypanosoma cruzi therapeutic vaccine re-programs immune response and reverses chronic cardiomyopathy.
Pereira IR, Vilar-Pereira G, Marques V, da Silva AA, Caetano B, Moreira OC, Machado AV, Bruna-Romero O, Rodrigues MM, Gazzinelli RT, Lannes-Vieira J. Pereira IR, et al. Among authors: rodrigues mm. PLoS Pathog. 2015 Jan 24;11(1):e1004594. doi: 10.1371/journal.ppat.1004594. eCollection 2015 Jan. PLoS Pathog. 2015. PMID: 25617628 Free PMC article.
The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi.
Ersching J, Vasconcelos JR, Ferreira CP, Caetano BC, Machado AV, Bruna-Romero O, Baron MA, Ferreira LR, Cunha-Neto E, Rock KL, Gazzinelli RT, Rodrigues MM. Ersching J, et al. Among authors: rodrigues mm. PLoS Pathog. 2016 Apr 29;12(4):e1005593. doi: 10.1371/journal.ppat.1005593. eCollection 2016 Apr. PLoS Pathog. 2016. PMID: 27128676 Free PMC article.
Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.
Dos Santos LI, Galvão-Filho B, de Faria PC, Junqueira C, Dutra MS, Teixeira SM, Rodrigues MM, Ritter G, Bannard O, Fearon DT, Antonelli LR, Gazzinelli RT. Dos Santos LI, et al. Among authors: rodrigues mm. Cancer Immunol Immunother. 2015 Mar;64(3):311-23. doi: 10.1007/s00262-014-1634-8. Epub 2014 Nov 18. Cancer Immunol Immunother. 2015. PMID: 25403749 Free PMC article.
Adenovirus vector-induced CD8⁺ T effector memory cell differentiation and recirculation, but not proliferation, are important for protective immunity against experimental Trypanosoma cruzi Infection.
Vasconcelos JR, Dominguez MR, Neves RL, Ersching J, Araújo A, Santos LI, Virgilio FS, Machado AV, Bruna-Romero O, Gazzinelli RT, Rodrigues MM. Vasconcelos JR, et al. Among authors: rodrigues mm. Hum Gene Ther. 2014 Apr;25(4):350-63. doi: 10.1089/hum.2013.218. Epub 2014 Mar 31. Hum Gene Ther. 2014. PMID: 24568548 Free PMC article.
Protective immunity against trypanosoma cruzi infection in a highly susceptible mouse strain after vaccination with genes encoding the amastigote surface protein-2 and trans-sialidase.
Vasconcelos JR, Hiyane MI, Marinho CR, Claser C, Machado AM, Gazzinelli RT, Bruña-Romero O, Alvarez JM, Boscardin SB, Rodrigues MM. Vasconcelos JR, et al. Among authors: rodrigues mm. Hum Gene Ther. 2004 Sep;15(9):878-86. doi: 10.1089/hum.2004.15.878. Hum Gene Ther. 2004. PMID: 15353042
417 results