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Vaccination using recombinants influenza and adenoviruses encoding amastigote surface protein-2 are highly effective on protection against Trypanosoma cruzi infection.
Barbosa RP, Filho BG, Dos Santos LI, Junior PA, Marques PE, Pereira RV, Cara DC, Bruña-Romero O, Rodrigues MM, Gazzinelli RT, Machado AV. Barbosa RP, et al. Among authors: machado av. PLoS One. 2013 Apr 24;8(4):e61795. doi: 10.1371/journal.pone.0061795. Print 2013. PLoS One. 2013. PMID: 23637908 Free PMC article.
The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi.
Ersching J, Vasconcelos JR, Ferreira CP, Caetano BC, Machado AV, Bruna-Romero O, Baron MA, Ferreira LR, Cunha-Neto E, Rock KL, Gazzinelli RT, Rodrigues MM. Ersching J, et al. Among authors: machado av. PLoS Pathog. 2016 Apr 29;12(4):e1005593. doi: 10.1371/journal.ppat.1005593. eCollection 2016 Apr. PLoS Pathog. 2016. PMID: 27128676 Free PMC article.
A human type 5 adenovirus-based Trypanosoma cruzi therapeutic vaccine re-programs immune response and reverses chronic cardiomyopathy.
Pereira IR, Vilar-Pereira G, Marques V, da Silva AA, Caetano B, Moreira OC, Machado AV, Bruna-Romero O, Rodrigues MM, Gazzinelli RT, Lannes-Vieira J. Pereira IR, et al. Among authors: machado av. PLoS Pathog. 2015 Jan 24;11(1):e1004594. doi: 10.1371/journal.ppat.1004594. eCollection 2015 Jan. PLoS Pathog. 2015. PMID: 25617628 Free PMC article.
Strain-specific protective immunity following vaccination against experimental Trypanosoma cruzi infection.
Haolla FA, Claser C, de Alencar BC, Tzelepis F, de Vasconcelos JR, de Oliveira G, Silvério JC, Machado AV, Lannes-Vieira J, Bruna-Romero O, Gazzinelli RT, dos Santos RR, Soares MB, Rodrigues MM. Haolla FA, et al. Among authors: machado av. Vaccine. 2009 Sep 18;27(41):5644-53. doi: 10.1016/j.vaccine.2009.07.013. Epub 2009 Jul 25. Vaccine. 2009. PMID: 19635607 Free article.
Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell-dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccination.
de Alencar BC, Persechini PM, Haolla FA, de Oliveira G, Silverio JC, Lannes-Vieira J, Machado AV, Gazzinelli RT, Bruna-Romero O, Rodrigues MM. de Alencar BC, et al. Among authors: machado av. Infect Immun. 2009 Oct;77(10):4383-95. doi: 10.1128/IAI.01459-08. Epub 2009 Aug 3. Infect Immun. 2009. PMID: 19651871 Free PMC article.
Heterologous plasmid DNA prime-recombinant human adenovirus 5 boost vaccination generates a stable pool of protective long-lived CD8(+) T effector memory cells specific for a human parasite, Trypanosoma cruzi.
Rigato PO, de Alencar BC, de Vasconcelos JR, Dominguez MR, Araújo AF, Machado AV, Gazzinelli RT, Bruna-Romero O, Rodrigues MM. Rigato PO, et al. Among authors: machado av. Infect Immun. 2011 May;79(5):2120-30. doi: 10.1128/IAI.01190-10. Epub 2011 Feb 28. Infect Immun. 2011. PMID: 21357719 Free PMC article.
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