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The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.
Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. Gozani O, et al. Cell. 2003 Jul 11;114(1):99-111. doi: 10.1016/s0092-8674(03)00480-x. Cell. 2003. PMID: 12859901 Free article.
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.
Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Peña P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze TG, Shi Y, Côté J, Chua KF, Gozani O. Shi X, et al. Among authors: gozani o. Nature. 2006 Jul 6;442(7098):96-9. doi: 10.1038/nature04835. Epub 2006 May 21. Nature. 2006. PMID: 16728974 Free PMC article.
Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36.
Shi X, Kachirskaia I, Walter KL, Kuo JH, Lake A, Davrazou F, Chan SM, Martin DG, Fingerman IM, Briggs SD, Howe L, Utz PJ, Kutateladze TG, Lugovskoy AA, Bedford MT, Gozani O. Shi X, et al. Among authors: gozani o. J Biol Chem. 2007 Jan 26;282(4):2450-5. doi: 10.1074/jbc.C600286200. Epub 2006 Dec 1. J Biol Chem. 2007. PMID: 17142463 Free PMC article.
Modulation of p53 function by SET8-mediated methylation at lysine 382.
Shi X, Kachirskaia I, Yamaguchi H, West LE, Wen H, Wang EW, Dutta S, Appella E, Gozani O. Shi X, et al. Among authors: gozani o. Mol Cell. 2007 Aug 17;27(4):636-46. doi: 10.1016/j.molcel.2007.07.012. Mol Cell. 2007. PMID: 17707234 Free PMC article.
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.
Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA. Matthews AG, et al. Among authors: gozani o. Nature. 2007 Dec 13;450(7172):1106-10. doi: 10.1038/nature06431. Epub 2007 Nov 21. Nature. 2007. PMID: 18033247 Free PMC article.
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O, Chua KF. Michishita E, et al. Among authors: gozani o. Nature. 2008 Mar 27;452(7186):492-6. doi: 10.1038/nature06736. Epub 2008 Mar 12. Nature. 2008. PMID: 18337721 Free PMC article.
123 results