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High-level semi-synthetic production of the potent antimalarial artemisinin.
Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Jiang H, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling KK, Renninger NS, Newman JD. Paddon CJ, et al. Among authors: mcphee d. Nature. 2013 Apr 25;496(7446):528-32. doi: 10.1038/nature12051. Epub 2013 Apr 10. Nature. 2013. PMID: 23575629
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin.
Westfall PJ, Pitera DJ, Lenihan JR, Eng D, Woolard FX, Regentin R, Horning T, Tsuruta H, Melis DJ, Owens A, Fickes S, Diola D, Benjamin KR, Keasling JD, Leavell MD, McPhee DJ, Renninger NS, Newman JD, Paddon CJ. Westfall PJ, et al. Among authors: mcphee dj. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):E111-8. doi: 10.1073/pnas.1110740109. Epub 2012 Jan 12. Proc Natl Acad Sci U S A. 2012. PMID: 22247290 Free PMC article.
Molecules Best Paper Award 2012.
McPhee DJ. McPhee DJ. Molecules. 2012 Feb 10;17(2):1795-6. doi: 10.3390/molecules17021795. Molecules. 2012. PMID: 23442982 Free PMC article. No abstract available.
Molecules Best Paper Award 2014.
McPhee DJ. McPhee DJ. Molecules. 2014 Jan 22;19(1):1375-7. doi: 10.3390/molecules19011375. Molecules. 2014. PMID: 24451257 Free PMC article. No abstract available.
145 results