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Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease.
Zhu Q, Korenfeld D, Suarez-Fueyo A, Graham S, Jin L, Punit S, Duffy R, Puri M, Caruso A, Hu C, Tian Y, McRae BL, Kamath R, Phillips L, Schwartz-Sterman AJ, Westmoreland S, Cao X, Levesque MC, Bi Y, Paez-Cortez J, Goenka R. Zhu Q, et al. Among authors: mcrae bl. Mucosal Immunol. 2022 Jun;15(6):1338-1349. doi: 10.1038/s41385-022-00577-w. Epub 2022 Nov 13. Mucosal Immunol. 2022. PMID: 36372810 Free article.
DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids.
Flood P, Fanning A, Woznicki JA, Crowley T, Christopher A, Vaccaro A, Houston A, McSweeney S, Ross S, Hogan A, Brint E, Skowyra A, Bustamante M, Ambrose M, Moloney G, MacSharry J, Hammarström ML, Hurley M, Fitzgibbons C, Quigley EMM, Shanahan F, Zulquernain SA, McCarthy J, Dodson GS, Dabbagh K, McRae BL, Melgar S, Nally K. Flood P, et al. Among authors: mcrae bl. Am J Physiol Gastrointest Liver Physiol. 2022 Nov 1;323(5):G439-G460. doi: 10.1152/ajpgi.00104.2022. Epub 2022 Sep 27. Am J Physiol Gastrointest Liver Physiol. 2022. PMID: 36165492 Free article.
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells.
Woznicki JA, Saini N, Flood P, Rajaram S, Lee CM, Stamou P, Skowyra A, Bustamante-Garrido M, Regazzoni K, Crawford N, McDade SS, Longley DB, Aza-Blanc P, Shanahan F, Zulquernain SA, McCarthy J, Melgar S, McRae BL, Nally K. Woznicki JA, et al. Among authors: mcrae bl. Cell Death Dis. 2021 Sep 23;12(10):864. doi: 10.1038/s41419-021-04151-3. Cell Death Dis. 2021. PMID: 34556638 Free PMC article.
Near infrared readouts offer sensitive and rapid assessments of intestinal permeability and disease severity in inflammatory bowel disease models.
Zhang L, Wallace CD, Erickson JE, Nelson CM, Gaudette SM, Pohl CS, Karsen SD, Simler GH, Peng R, Stedman CA, Laroux FS, Wurbel MA, Kamath RV, McRae BL, Schwartz Sterman AJ, Mitra S. Zhang L, et al. Among authors: mcrae bl. Sci Rep. 2020 Mar 13;10(1):4696. doi: 10.1038/s41598-020-61756-y. Sci Rep. 2020. PMID: 32170183 Free PMC article.
CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.
Argiriadi MA, Benatuil L, Dubrovska I, Egan DA, Gao L, Greischar A, Hardman J, Harlan J, Iyer RB, Judge RA, Lake M, Perron DC, Sadhukhan R, Sielaff B, Sousa S, Wang R, McRae BL. Argiriadi MA, et al. Among authors: mcrae bl. BMC Mol Cell Biol. 2019 Aug 5;20(1):29. doi: 10.1186/s12860-019-0213-4. BMC Mol Cell Biol. 2019. PMID: 31382872 Free PMC article.
34 results