Leal SM - Search Results

1

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants.

Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Rieder MJ, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ; NHLBI Exome Sequencing Project; Akey JM. Fu W, et al. Among authors: leal sm. Nature. 2013 Jan 10;493(7431):216-20. doi: 10.1038/nature11690. Epub 2012 Nov 28. Nature. 2013. PMID: 23201682 Free PMC article.

2

Ignoring intermarker linkage disequilibrium induces false-positive evidence of linkage for consanguineous pedigrees when genotype data is missing for any pedigree member.

Li B, Leal SM. Li B, et al. Among authors: leal sm. Hum Hered. 2008;65(4):199-208. doi: 10.1159/000112367. Epub 2007 Dec 11. Hum Hered. 2008. PMID: 18073490 Free PMC article.

3

Sequence variants in host cell factor C1 are associated with Ménière's disease.

Vrabec JT, Liu L, Li B, Leal SM. Vrabec JT, et al. Among authors: leal sm. Otol Neurotol. 2008 Jun;29(4):561-6. doi: 10.1097/MAO.0b013e318168d23b. Otol Neurotol. 2008. PMID: 18520591 Free PMC article.

4

Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data.

Li B, Leal SM. Li B, et al. Among authors: leal sm. Am J Hum Genet. 2008 Sep;83(3):311-21. doi: 10.1016/j.ajhg.2008.06.024. Epub 2008 Aug 7. Am J Hum Genet. 2008. PMID: 18691683 Free PMC article.

5

Deviations from hardy-weinberg equilibrium in parental and unaffected sibling genotype data.

Li B, Leal SM. Li B, et al. Among authors: leal sm. Hum Hered. 2009;67(2):104-15. doi: 10.1159/000179558. Epub 2008 Dec 12. Hum Hered. 2009. PMID: 19077427 Free PMC article.

6

Discovery of rare variants via sequencing: implications for the design of complex trait association studies.

Li B, Leal SM. Li B, et al. Among authors: leal sm. PLoS Genet. 2009 May;5(5):e1000481. doi: 10.1371/journal.pgen.1000481. Epub 2009 May 15. PLoS Genet. 2009. PMID: 19436704 Free PMC article.

7

A novel adaptive method for the analysis of next-generation sequencing data to detect complex trait associations with rare variants due to gene main effects and interactions.

Liu DJ, Leal SM. Liu DJ, et al. Among authors: leal sm. PLoS Genet. 2010 Oct 14;6(10):e1001156. doi: 10.1371/journal.pgen.1001156. PLoS Genet. 2010. PMID: 20976247 Free PMC article.

8

GENOME-WIDE ASSOCIATION MAPPING AND RARE ALLELES: FROM POPULATION GENOMICS TO PERSONALIZED MEDICINE - Session Introduction.

DE LA Vega FM, Bustamante CD, Leal SM. DE LA Vega FM, et al. Among authors: leal sm. Pac Symp Biocomput. 2011:74-5. doi: 10.1142/9789814335058_0008. Pac Symp Biocomput. 2011. PMID: 21121034 Free PMC article.

9

Replication strategies for rare variant complex trait association studies via next-generation sequencing.

Liu DJ, Leal SM. Liu DJ, et al. Among authors: leal sm. Am J Hum Genet. 2010 Dec 10;87(6):790-801. doi: 10.1016/j.ajhg.2010.10.025. Am J Hum Genet. 2010. PMID: 21129725 Free PMC article.

10

Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia.

Brautbar A, Covarrubias D, Belmont J, Lara-Garduno F, Virani SS, Jones PH, Leal SM, Ballantyne CM. Brautbar A, et al. Among authors: leal sm. Atherosclerosis. 2011 Dec;219(2):737-42. doi: 10.1016/j.atherosclerosis.2011.08.015. Epub 2011 Aug 22. Atherosclerosis. 2011. PMID: 21889769 Free PMC article. Clinical Trial.

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