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IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules.
Orabi AI, Luo Y, Ahmad MU, Shah AU, Mannan Z, Wang D, Sarwar S, Muili KA, Shugrue C, Kolodecik TR, Singh VP, Lowe ME, Thrower E, Chen J, Husain SZ. Orabi AI, et al. Among authors: shah au. PLoS One. 2012;7(11):e48465. doi: 10.1371/journal.pone.0048465. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185258 Free PMC article.
Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury.
Muili KA, Ahmad M, Orabi AI, Mahmood SM, Shah AU, Molkentin JD, Husain SZ. Muili KA, et al. Among authors: shah au. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G898-905. doi: 10.1152/ajpgi.00545.2011. Epub 2012 Feb 9. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 22323127 Free PMC article.
The ryanodine receptor is expressed in human pancreatic acinar cells and contributes to acinar cell injury.
Lewarchik CM, Orabi AI, Jin S, Wang D, Muili KA, Shah AU, Eisses JF, Malik A, Bottino R, Jayaraman T, Husain SZ. Lewarchik CM, et al. Among authors: shah au. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G574-81. doi: 10.1152/ajpgi.00143.2014. Epub 2014 Jul 10. Am J Physiol Gastrointest Liver Physiol. 2014. PMID: 25012845 Free PMC article.
Cyclic AMP accelerates calcium waves in pancreatic acinar cells.
Shah AU, Grant WM, Latif SU, Mannan ZM, Park AJ, Husain SZ. Shah AU, et al. Am J Physiol Gastrointest Liver Physiol. 2008 Jun;294(6):G1328-34. doi: 10.1152/ajpgi.00440.2007. Epub 2008 Apr 3. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18388188 Free PMC article.
Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice.
Orabi AI, Shah AU, Ahmad MU, Choo-Wing R, Parness J, Jain D, Bhandari V, Husain SZ. Orabi AI, et al. Among authors: shah au. Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G196-204. doi: 10.1152/ajpgi.00498.2009. Epub 2010 May 6. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 20448143 Free PMC article.
82 results