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Interruption of the ionic lock in the bradykinin B2 receptor results in constitutive internalization and turns several antagonists into strong agonists.
J Pharmacol Exp Ther. 2013 Jan;344(1):85-95. doi: 10.1124/jpet.112.199190. Epub 2012 Oct 18.
J Pharmacol Exp Ther. 2013.
PMID: 23086229
Alanine screening of the intracellular loops of the human bradykinin B receptor--effects on receptor maintenance, G protein activation and internalization.
Faussner A, Wennerberg G, Schüssler S, Feierler J, Seidl C, Jochum M, Proud D.
Faussner A, et al. Among authors: wennerberg g.
FEBS J. 2009 Jul;276(13):3491-503. doi: 10.1111/j.1742-4658.2009.07071.x. Epub 2009 May 18.
FEBS J. 2009.
PMID: 19456859
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