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Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides.
Asami T, Nishizawa N, Ishibashi Y, Nishibori K, Nakayama M, Horikoshi Y, Matsumoto S, Yamaguchi M, Matsumoto H, Tarui N, Ohtaki T, Kitada C. Asami T, et al. Among authors: tarui n. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6391-6. doi: 10.1016/j.bmcl.2012.08.069. Epub 2012 Aug 23. Bioorg Med Chem Lett. 2012. PMID: 22975302
Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity.
Asami T, Nishizawa N, Matsui H, Takatsu Y, Suzuki A, Kiba A, Terada M, Nishibori K, Nakayama M, Ban J, Matsumoto S, Tarui N, Ikeda Y, Yamaguchi M, Kusaka M, Ohtaki T, Kitada C. Asami T, et al. Among authors: tarui n. J Med Chem. 2014 Jul 24;57(14):6105-15. doi: 10.1021/jm5005489. Epub 2014 Jul 7. J Med Chem. 2014. PMID: 24918545
Novel 3-phenylpiperidine-4-carboxamides as highly potent and orally long-acting neurokinin-1 receptor antagonists with reduced CYP3A induction.
Shirai J, Sugiyama H, Morimoto S, Maezaki H, Yamamoto Y, Okanishi S, Kamo I, Matsumoto S, Ishigami K, Inatomi N, Imanishi A, Kawamoto M, Tarui N, Hashimoto T, Ikeura Y. Shirai J, et al. Among authors: tarui n. Bioorg Med Chem. 2012 Jan 15;20(2):962-77. doi: 10.1016/j.bmc.2011.11.048. Epub 2011 Dec 1. Bioorg Med Chem. 2012. PMID: 22189275
Novel approach of fragment-based lead discovery applied to renin inhibitors.
Tawada M, Suzuki S, Imaeda Y, Oki H, Snell G, Behnke CA, Kondo M, Tarui N, Tanaka T, Kuroita T, Tomimoto M. Tawada M, et al. Among authors: tarui n. Bioorg Med Chem. 2016 Nov 15;24(22):6066-6074. doi: 10.1016/j.bmc.2016.09.065. Epub 2016 Sep 28. Bioorg Med Chem. 2016. PMID: 27720325
Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.
Imaeda T, Ono K, Nakai K, Hori Y, Matsukawa J, Takagi T, Fujioka Y, Tarui N, Kondo M, Imanishi A, Inatomi N, Kajino M, Itoh F, Nishida H. Imaeda T, et al. Among authors: tarui n. Bioorg Med Chem. 2017 Jul 15;25(14):3719-3735. doi: 10.1016/j.bmc.2017.05.012. Epub 2017 May 6. Bioorg Med Chem. 2017. PMID: 28522264
23 results