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Blocking antibody to the β-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis.
Zhu LL, Blair H, Cao J, Yuen T, Latif R, Guo L, Tourkova IL, Li J, Davies TF, Sun L, Bian Z, Rosen C, Zallone A, New MI, Zaidi M. Zhu LL, et al. Among authors: sun l. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14574-9. doi: 10.1073/pnas.1212806109. Epub 2012 Aug 20. Proc Natl Acad Sci U S A. 2012. PMID: 22908268 Free PMC article.
Calcineurin regulates bone formation by the osteoblast.
Sun L, Blair HC, Peng Y, Zaidi N, Adebanjo OA, Wu XB, Wu XY, Iqbal J, Epstein S, Abe E, Moonga BS, Zaidi M. Sun L, et al. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17130-5. doi: 10.1073/pnas.0508480102. Epub 2005 Nov 14. Proc Natl Acad Sci U S A. 2005. PMID: 16286645 Free PMC article.
FSH directly regulates bone mass.
Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M. Sun L, et al. Cell. 2006 Apr 21;125(2):247-60. doi: 10.1016/j.cell.2006.01.051. Cell. 2006. PMID: 16630814 Free article.
TSH and bone loss.
Sun L, Davies TF, Blair HC, Abe E, Zaidi M. Sun L, et al. Ann N Y Acad Sci. 2006 Apr;1068:309-18. doi: 10.1196/annals.1346.033. Ann N Y Acad Sci. 2006. PMID: 16831931 Review.
TNFalpha mediates the skeletal effects of thyroid-stimulating hormone.
Hase H, Ando T, Eldeiry L, Brebene A, Peng Y, Liu L, Amano H, Davies TF, Sun L, Zaidi M, Abe E. Hase H, et al. Among authors: sun l. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12849-54. doi: 10.1073/pnas.0600427103. Epub 2006 Aug 14. Proc Natl Acad Sci U S A. 2006. PMID: 16908863 Free PMC article.
Proresorptive actions of FSH and bone loss.
Zaidi M, Blair HC, Iqbal J, Zhu LL, Kumar TR, Zallone A, Sun L. Zaidi M, et al. Among authors: sun l. Ann N Y Acad Sci. 2007 Nov;1116:376-82. doi: 10.1196/annals.1402.056. Ann N Y Acad Sci. 2007. PMID: 18083939 Review.
Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss.
Sun L, Vukicevic S, Baliram R, Yang G, Sendak R, McPherson J, Zhu LL, Iqbal J, Latif R, Natrajan A, Arabi A, Yamoah K, Moonga BS, Gabet Y, Davies TF, Bab I, Abe E, Sampath K, Zaidi M. Sun L, et al. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4289-94. doi: 10.1073/pnas.0712395105. Epub 2008 Mar 10. Proc Natl Acad Sci U S A. 2008. PMID: 18332426 Free PMC article.
Thyroid-stimulating hormone, thyroid hormones, and bone loss.
Zaidi M, Davies TF, Zallone A, Blair HC, Iqbal J, Moonga SS, Mechanick J, Sun L. Zaidi M, et al. Among authors: sun l. Curr Osteoporos Rep. 2009 Jul;7(2):47-52. doi: 10.1007/s11914-009-0009-0. Curr Osteoporos Rep. 2009. PMID: 19631028
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