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Structure of a specialized acyl carrier protein essential for lipid A biosynthesis with very long-chain fatty acids in open and closed conformations.
Ramelot TA, Rossi P, Forouhar F, Lee HW, Yang Y, Ni S, Unser S, Lew S, Seetharaman J, Xiao R, Acton TB, Everett JK, Prestegard JH, Hunt JF, Montelione GT, Kennedy MA. Ramelot TA, et al. Among authors: forouhar f. Biochemistry. 2012 Sep 18;51(37):7239-49. doi: 10.1021/bi300546b. Epub 2012 Sep 7. Biochemistry. 2012. PMID: 22876860 Free PMC article.
Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds.
Forouhar F, Hussain M, Farid R, Benach J, Abashidze M, Edstrom WC, Vorobiev SM, Xiao R, Acton TB, Fu Z, Kim JJ, Miziorko HM, Montelione GT, Hunt JF. Forouhar F, et al. J Biol Chem. 2006 Mar 17;281(11):7533-45. doi: 10.1074/jbc.M507996200. Epub 2005 Dec 5. J Biol Chem. 2006. PMID: 16330546 Free article.
Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase.
Forouhar F, Anderson JL, Mowat CG, Vorobiev SM, Hussain A, Abashidze M, Bruckmann C, Thackray SJ, Seetharaman J, Tucker T, Xiao R, Ma LC, Zhao L, Acton TB, Montelione GT, Chapman SK, Tong L. Forouhar F, et al. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):473-8. doi: 10.1073/pnas.0610007104. Epub 2006 Dec 29. Proc Natl Acad Sci U S A. 2007. PMID: 17197414 Free PMC article.
Functional insights from structural genomics.
Forouhar F, Kuzin A, Seetharaman J, Lee I, Zhou W, Abashidze M, Chen Y, Yong W, Janjua H, Fang Y, Wang D, Cunningham K, Xiao R, Acton TB, Pichersky E, Klessig DF, Porter CW, Montelione GT, Tong L. Forouhar F, et al. J Struct Funct Genomics. 2007 Sep;8(2-3):37-44. doi: 10.1007/s10969-007-9018-3. Epub 2007 Jun 23. J Struct Funct Genomics. 2007. PMID: 17588214
153 results