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Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epithelia.
Schwarzer C, Wong S, Shi J, Matthes E, Illek B, Ianowski JP, Arant RJ, Isacoff E, Vais H, Foskett JK, Maiellaro I, Hofer AM, Machen TE. Schwarzer C, et al. Among authors: ianowski jp. J Biol Chem. 2010 Nov 5;285(45):34850-63. doi: 10.1074/jbc.M110.167668. Epub 2010 Aug 25. J Biol Chem. 2010. PMID: 20739289 Free PMC article.
Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens.
Luan X, Belev G, Tam JS, Jagadeeshan S, Hassan N, Gioino P, Grishchenko N, Huang Y, Carmalt JL, Duke T, Jones T, Monson B, Burmester M, Simovich T, Yilmaz O, Campanucci VA, Machen TE, Chapman LD, Ianowski JP. Luan X, et al. Among authors: ianowski jp. Nat Commun. 2017 Oct 5;8(1):786. doi: 10.1038/s41467-017-00835-7. Nat Commun. 2017. PMID: 28983075 Free PMC article.
Airway submucosal glands from cystic fibrosis swine suffer from abnormal ion transport across the serous acini, collecting duct, and ciliated duct.
Luan X, Tam JS, Jagadeeshan S, Grishchenko N, Hassan N, Gioino P, Shipley AM, Machen TE, Ianowski JP. Luan X, et al. Among authors: ianowski jp. Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L931-L942. doi: 10.1152/ajplung.00219.2019. Epub 2020 Mar 4. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32130033 Free article.
33 results