Mitscher LA - Search Results

1

Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors.

Pajouhesh H, Feng ZP, Zhang L, Pajouhesh H, Jiang X, Hendricson A, Dong H, Tringham E, Ding Y, Vanderah TW, Porreca F, Belardetti F, Zamponi GW, Mitscher LA, Snutch TP. Pajouhesh H, et al. Among authors: mitscher la. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4153-8. doi: 10.1016/j.bmcl.2012.04.054. Epub 2012 Apr 19. Bioorg Med Chem Lett. 2012. PMID: 22579422 Free article.

2

Scaffold-based design and synthesis of potent N-type calcium channel blockers.

Zamponi GW, Feng ZP, Zhang L, Pajouhesh H, Ding Y, Belardetti F, Pajouhesh H, Dolphin D, Mitscher LA, Snutch TP. Zamponi GW, et al. Among authors: mitscher la. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72. doi: 10.1016/j.bmcl.2009.09.008. Epub 2009 Sep 11. Bioorg Med Chem Lett. 2009. PMID: 19815411

3

Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors.

Pajouhesh H, Feng ZP, Ding Y, Zhang L, Pajouhesh H, Morrison JL, Belardetti F, Tringham E, Simonson E, Vanderah TW, Porreca F, Zamponi GW, Mitscher LA, Snutch TP. Pajouhesh H, et al. Among authors: mitscher la. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1378-83. doi: 10.1016/j.bmcl.2010.01.008. Epub 2010 Jan 7. Bioorg Med Chem Lett. 2010. PMID: 20117000

4

Butitaxel analogues: synthesis and structure-activity relationships.

Ali SM, Hoemann MZ, Aubé J, Georg GI, Mitscher LA, Jayasinghe LR. Ali SM, et al. Among authors: mitscher la. J Med Chem. 1997 Jan 17;40(2):236-41. doi: 10.1021/jm960505t. J Med Chem. 1997. PMID: 9003522

5

Structure-activity relationships among DNA gyrase inhibitors. Synthesis and biological evaluation of 1,2-dihydro-4, 4-dimethyl-1-oxo-2-naphthalenecarboxylic acids as 1-carba bioisosteres of oxolinic acid.

Högberg T, Khanna I, Drake SD, Mitscher LA, Shen LL. Högberg T, et al. Among authors: mitscher la. J Med Chem. 1984 Mar;27(3):306-10. doi: 10.1021/jm00369a013. J Med Chem. 1984. PMID: 6321736

6

Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues.

Ahn YM, Vogeti L, Liu CJ, Santhapuram HK, White JM, Vasandani V, Mitscher LA, Lushington GH, Hanson PR, Powell DR, Himes RH, Roby KF, Ye Q, Georg GI. Ahn YM, et al. Among authors: mitscher la. Bioorg Med Chem. 2007 Jan 15;15(2):702-13. doi: 10.1016/j.bmc.2006.10.063. Epub 2006 Nov 1. Bioorg Med Chem. 2007. PMID: 17123821 Free PMC article.

7

Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid.

Mitscher LA, Sharma PN, Chu DT, Shen LL, Pernet AG. Mitscher LA, et al. J Med Chem. 1986 Oct;29(10):2044-7. doi: 10.1021/jm00160a042. J Med Chem. 1986. PMID: 3020253

8

Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure-activity studies on juncusol.

Boger DL, Mitscher LA, Mullican MD, Drake SD, Kitos P. Boger DL, et al. Among authors: mitscher la. J Med Chem. 1985 Oct;28(10):1543-7. doi: 10.1021/jm00148a031. J Med Chem. 1985. PMID: 4045930

9

Chiral DNA gyrase inhibitors. 3. Probing the chiral preference of the active site of DNA gyrase. Synthesis of 10-fluoro-6-methyl-6,7-dihydro-9-piperazinyl- 2H-benzo[a]quinolizin-20-one-3-carboxylic acid analogues.

Fecik RA, Devasthale P, Pillai S, Keschavarz-Shokri A, Shen L, Mitscher LA. Fecik RA, et al. Among authors: mitscher la. J Med Chem. 2005 Feb 24;48(4):1229-36. doi: 10.1021/jm0401356. J Med Chem. 2005. PMID: 15715489

10

The search for orally active medications through combinatorial chemistry.

Fecik RA, Frank KE, Gentry EJ, Menon SR, Mitscher LA, Telikepalli H. Fecik RA, et al. Among authors: mitscher la. Med Res Rev. 1998 May;18(3):149-85. doi: 10.1002/(sici)1098-1128(199805)18:3<149::aid-med2>3.0.co;2-x. Med Res Rev. 1998. PMID: 9578985 Review.

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