Fanjul A - Search Results

1

From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer.

Lapuk AV, Wu C, Wyatt AW, McPherson A, McConeghy BJ, Brahmbhatt S, Mo F, Zoubeidi A, Anderson S, Bell RH, Haegert A, Shukin R, Wang Y, Fazli L, Hurtado-Coll A, Jones EC, Hach F, Hormozdiari F, Hajirasouliha I, Boutros PC, Bristow RG, Zhao Y, Marra MA, Fanjul A, Maher CA, Chinnaiyan AM, Rubin MA, Beltran H, Sahinalp SC, Gleave ME, Volik SV, Collins CC. Lapuk AV, et al. Among authors: fanjul a. J Pathol. 2012 Jul;227(3):286-97. doi: 10.1002/path.4047. J Pathol. 2012. PMID: 22553170 Free PMC article.

2

A novel antiandrogen, Compound 30, suppresses castration-resistant and MDV3100-resistant prostate cancer growth in vitro and in vivo.

Kuruma H, Matsumoto H, Shiota M, Bishop J, Lamoureux F, Thomas C, Briere D, Los G, Gleave M, Fanjul A, Zoubeidi A. Kuruma H, et al. Among authors: fanjul a. Mol Cancer Ther. 2013 May;12(5):567-76. doi: 10.1158/1535-7163.MCT-12-0798. Epub 2013 Mar 14. Mol Cancer Ther. 2013. PMID: 23493310

3

Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists.

Guo C, Linton A, Kephart S, Ornelas M, Pairish M, Gonzalez J, Greasley S, Nagata A, Burke BJ, Edwards M, Hosea N, Kang P, Hu W, Engebretsen J, Briere D, Shi M, Gukasyan H, Richardson P, Dack K, Underwood T, Johnson P, Morell A, Felstead R, Kuruma H, Matsimoto H, Zoubeidi A, Gleave M, Los G, Fanjul AN. Guo C, et al. Among authors: fanjul an. J Med Chem. 2011 Nov 10;54(21):7693-704. doi: 10.1021/jm201059s. Epub 2011 Oct 7. J Med Chem. 2011. PMID: 21936524

4

Dose-dependent effects of small-molecule antagonists on the genomic landscape of androgen receptor binding.

Zhu Z, Shi M, Hu W, Estrella H, Engebretsen J, Nichols T, Briere D, Hosea N, Los G, Rejto PA, Fanjul A. Zhu Z, et al. Among authors: fanjul a. BMC Genomics. 2012 Jul 31;13:355. doi: 10.1186/1471-2164-13-355. BMC Genomics. 2012. PMID: 22849360 Free PMC article.

5

A selective retinoid with high activity against an androgen-resistant prostate cancer cell type.

Lu XP, Fanjul A, Picard N, Shroot B, Pfahl M. Lu XP, et al. Among authors: fanjul a. Int J Cancer. 1999 Jan 18;80(2):272-8. doi: 10.1002/(sici)1097-0215(19990118)80:2<272::aid-ijc17>3.0.co;2-x. Int J Cancer. 1999. PMID: 9935210 Free article.

6

Apoptosis induction and potent antiestrogen receptor-negative breast cancer activity in vivo by a retinoid antagonist.

Fanjul AN, Piedrafita FJ, Al-Shamma H, Pfahl M. Fanjul AN, et al. Cancer Res. 1998 Oct 15;58(20):4607-10. Cancer Res. 1998. PMID: 9788611

7

Discovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer.

Guo C, Kephart S, Ornelas M, Gonzalez J, Linton A, Pairish M, Nagata A, Greasley S, Elleraas J, Hosea N, Engebretsen J, Fanjul AN. Guo C, et al. Among authors: fanjul an. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1230-6. doi: 10.1016/j.bmcl.2011.11.068. Epub 2011 Dec 9. Bioorg Med Chem Lett. 2012. PMID: 22197140

8

Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists.

Guo C, Pairish M, Linton A, Kephart S, Ornelas M, Nagata A, Burke B, Dong L, Engebretsen J, Fanjul AN. Guo C, et al. Among authors: fanjul an. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2572-8. doi: 10.1016/j.bmcl.2012.01.116. Epub 2012 Feb 7. Bioorg Med Chem Lett. 2012. PMID: 22377517

9

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.

Siu M, Johnson TO, Wang Y, Nair SK, Taylor WD, Cripps SJ, Matthews JJ, Edwards MP, Pauly TA, Ermolieff J, Castro A, Hosea NA, LaPaglia A, Fanjul AN, Vogel JE. Siu M, et al. Among authors: fanjul an. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3493-7. doi: 10.1016/j.bmcl.2009.05.011. Epub 2009 May 7. Bioorg Med Chem Lett. 2009. PMID: 19473839

10

The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.

Cheng H, Hoffman J, Le P, Nair SK, Cripps S, Matthews J, Smith C, Yang M, Kupchinsky S, Dress K, Edwards M, Cole B, Walters E, Loh C, Ermolieff J, Fanjul A, Bhat GB, Herrera J, Pauly T, Hosea N, Paderes G, Rejto P. Cheng H, et al. Among authors: fanjul a. Bioorg Med Chem Lett. 2010 May 1;20(9):2897-902. doi: 10.1016/j.bmcl.2010.03.032. Epub 2010 Mar 10. Bioorg Med Chem Lett. 2010. PMID: 20363126

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